Table 3 Factors associated with infection outcomes per course of chemotherapy (N = 157)

Down syndrome-specific treatment protocol

0.42 (0.28, 0.64)

<0.0001

0.48 (0.29, 0.78)

0.003

0.25 (0.10, 0.60)

0.002

Age in years

1.01 (0.99, 1.03)

0.349

1.01 (0.98, 1.03)

0.577

1.01 (0.99, 1.03)

0.261

Diagnosed prior to January 1, 2000

0.79 (0.60, 1.03)

0.080

0.75 (0.56, 1.00)

0.052

0.95 (0.75, 1.22)

0.703

Cumulative dose of cytarabine (g/m²)

1.03 (1.02, 1.05)

0.0001

1.03 (1.01, 1.05)

0.001

0.99 (0.97, 1.01)

0.184

Neutropenia (ANC <0.5 ×10⁹) at start of course

1.01 (0.72, 1.43)

0.936

0.82 (0.56, 1.22)

0.336

1.88 (1.38, 2.56)

<0.0001

Greater than 15 days with neutropenia

2.50 (1.89, 3.32)

<0.0001

2.45 (1.83, 3.36)

<0.0001

2.81 (2.16, 3.66)

<0.0001

Days receiving steroids

1.08 (1.06, 1.11)

<0.0001

1.07 (1.05, 1.10)

<0.0001

1.07 (1.05, 1.09)

<0.0001