Infections in children with down syndrome and acute myeloid leukemia: a report from the Canadian infections in AML research group

Table 1 Characteristics of children with Down syndrome at diagnosis of acute myeloid leukemia (N = 31)

	DS-specific AML protocol (N = 11)	Non-DS specific AML protocol (N = 20)	P value
Child characteristics at diagnosis
Male (%)	9 (81.8)	11 (55.0)	0.241
Median age in years (IQR)	1.5 (0.8, 2.3)	2.2 (1.5, 2.9)	0.132
Median WBC (×10⁹/L)(IQR)	5.4 (3.1, 21.1)	7.6 (4.8, 16.7)	0.397
Median ANC (×10⁹/L)(IQR)^a	1.1 (0.6, 2.6)	1.6 (0.8, 4.1)	0.312
Median hemoglobin (g/L)(IQR)	82.0 (78.0, 107.0)	92.5 (59.0, 110.0)	0.870
Median platelet count (×10⁹/L )(IQR)^b	33.5 (12.0, 57.0)	44.0 (30.0, 77.0)	0.261
Cytogenetics (%)			0.392
Normal karyotype	2 (18.2)	1 (5.0)
t(8;21), inv16 or t(16;16)	0 (0.0)	1 (5.0)
11q23 abnormalities	0 (0.0)	2 (10.0)
Unknown	3 (27.3)	6 (30.0)
Other	6 (54.5)	10 (50.0)
Treatment characteristics
Registered on a study (%)	2 (18.2)	6 (30.0)	0.676
Time on any chemotherapy (median days) (IQR)	199.0 (177.0, 260.0)	168.5 (136.5, 225.0)	0.143
Time on intensive chemotherapy (median days) (IQR)	135.0 (120.0, 143.0)	153.5 (129.0, 214.0)	0.094

Abbreviations: IQR interquartile range, WBC white blood cell, ANC absolute neutrophil count, AML acute myeloid leukemia, DS Down syndrome.
^aANC not available at diagnosis for two patients in the non-Down syndrome protocol group.
^bPlatelet count not available at diagnosis for one patient in both groups.

ISSN: 1750-9378