Skip to main content

Table 1 Characteristics of children with Down syndrome at diagnosis of acute myeloid leukemia (N = 31)

From: Infections in children with down syndrome and acute myeloid leukemia: a report from the Canadian infections in AML research group

  DS-specific AML protocol (N = 11) Non-DS specific AML protocol (N = 20) P value
Child characteristics at diagnosis    
Male (%) 9 (81.8) 11 (55.0) 0.241
Median age in years (IQR) 1.5 (0.8, 2.3) 2.2 (1.5, 2.9) 0.132
Median WBC (×109/L)(IQR) 5.4 (3.1, 21.1) 7.6 (4.8, 16.7) 0.397
Median ANC (×109/L)(IQR)a 1.1 (0.6, 2.6) 1.6 (0.8, 4.1) 0.312
Median hemoglobin (g/L)(IQR) 82.0 (78.0, 107.0) 92.5 (59.0, 110.0) 0.870
Median platelet count (×109/L )(IQR)b 33.5 (12.0, 57.0) 44.0 (30.0, 77.0) 0.261
Cytogenetics (%)    0.392
  Normal karyotype 2 (18.2) 1 (5.0)  
  t(8;21), inv16 or t(16;16) 0 (0.0) 1 (5.0)  
  11q23 abnormalities 0 (0.0) 2 (10.0)  
  Unknown 3 (27.3) 6 (30.0)  
  Other 6 (54.5) 10 (50.0)  
Treatment characteristics    
Registered on a study (%) 2 (18.2) 6 (30.0) 0.676
Time on any chemotherapy (median days) (IQR) 199.0 (177.0, 260.0) 168.5 (136.5, 225.0) 0.143
Time on intensive chemotherapy (median days) (IQR) 135.0 (120.0, 143.0) 153.5 (129.0, 214.0) 0.094
  1. Abbreviations: IQR interquartile range, WBC white blood cell, ANC absolute neutrophil count, AML acute myeloid leukemia, DS Down syndrome.
  2. aANC not available at diagnosis for two patients in the non-Down syndrome protocol group.
  3. bPlatelet count not available at diagnosis for one patient in both groups.