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Table 1 Nucleotide sequence variations in the HPV 16 E6 gene of 142 HPV 16-positive French women

From: Human papillomavirus type 16 E6 variants in France and risk of viral persistence

Status

 

HPV 16 E6 nucleotide position

 

Clearance*

Persistence*

109

131

132

143

145

176

183

187

196

255

256

269

275

285

286

289

295

335

350

403

453

464

478

532

(sub-) lineage

N

N

T

A

G

C

G

G

T

A

G

G

C

G

A

C

T

A

T

C

T

A

G

A

C

A

Reference

13

29

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

EUR-350 T

6

6

0

0

0

0

0

0

0

0

0

0

-

-

-

-

-

-

-

-

-

0

0

0

0

0

EUR-350 T

0

1

-

-

-

-

-

C

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

EUR-350 T

0

1

-

-

-

-

-

-

-

G

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

EUR-350 T

0

1

-

-

-

-

-

-

-

-

-

-

-

A

-

-

-

-

-

-

-

-

-

-

-

-

EUR-350 T

0

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

G

-

-

EUR-350 T

22

27

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

G

-

-

-

-

-

EUR-350 G

9

9

0

0

0

0

0

0

0

0

0

0

-

-

-

-

-

-

-

-

G

0

0

0

0

0

EUR-350 G

0

3

C

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

G

-

-

-

-

-

EUR-350 G

0

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

G

-

T

-

-

-

EUR-350 G

0

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

G

-

-

-

A

-

EUR-350 G

1

0

-

-

-

-

-

-

-

-

-

-

-

-

G

-

-

-

-

-

G

-

-

-

-

-

EUR-350 G

0

1

-

-

-

-

T

-

-

-

-

-

-

-

-

-

A

G

-

T

G

-

-

-

-

-

NA (non-EUR)

1

1

-

-

C

G

T

-

-

-

-

-

-

-

-

-

A

G

-

T

-

-

-

-

-

-

AFR1 (non-EUR)

0

1

-

G

-

G

T

-

-

-

-

-

-

-

-

-

A

G

G

T

G

-

-

-

-

-

AFR1 (non-EUR)

2

1

C

-

T

G

T

-

-

-

-

-

-

-

-

-

A

G

-

T

-

G

-

-

-

-

AFR2 (non-EUR)

1

0

C

-

T

G

T

-

C

-

-

-

-

-

-

-

A

G

-

T

-

G

-

-

-

-

AFR2 (non-EUR)

0

1

C

-

T

G

T

-

-

-

-

-

-

-

-

G

A

G

-

T

-

G

-

-

-

-

AFR2 (non-EUR)

0

1

-

-

-

G

T

-

-

-

A

T

T

-

-

-

A

G

G

T

-

-

-

-

-

-

AFR2 (non-EUR)

1

0

-

-

-

G

T

-

-

-

-

-

-

-

-

-

A

G

-

T

-

-

-

-

-

-

AFR2 (non-EUR)

56

86

                         
  1. Sequence results are shown by outcome of infection: *Clearance (HPV16-negative at follow-up visit between 4–16 months) or *Persistence (HPV16-positive at follow-up visit between 4–16 months).
  2. Abbreviations: EUR EURopean, NA North American, AFR AFRican.
  3. 0 = failed sequencing for the whole E6 gene, a shorter fragment of E6 was determined (nt. 256–400).
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Infectious Agents and Cancer

ISSN: 1750-9378

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