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Table 1 Nucleotide sequence variations in the HPV 16 E6 gene of 142 HPV 16-positive French women

From: Human papillomavirus type 16 E6 variants in France and risk of viral persistence

Status   HPV 16 E6 nucleotide position  
Clearance* Persistence* 109 131 132 143 145 176 183 187 196 255 256 269 275 285 286 289 295 335 350 403 453 464 478 532 (sub-) lineage
N N T A G C G G T A G G C G A C T A T C T A G A C A Reference
13 29 - - - - - - - - - - - - - - - - - - - - - - - - EUR-350 T
6 6 0 0 0 0 0 0 0 0 0 0 - - - - - - - - - 0 0 0 0 0 EUR-350 T
0 1 - - - - - C - - - - - - - - - - - - - - - - - - EUR-350 T
0 1 - - - - - - - G - - - - - - - - - - - - - - - - EUR-350 T
0 1 - - - - - - - - - - - A - - - - - - - - - - - - EUR-350 T
0 1 - - - - - - - - - - - - - - - - - - - - - G - - EUR-350 T
22 27 - - - - - - - - - - - - - - - - - - G - - - - - EUR-350 G
9 9 0 0 0 0 0 0 0 0 0 0 - - - - - - - - G 0 0 0 0 0 EUR-350 G
0 3 C - - - - - - - - - - - - - - - - - G - - - - - EUR-350 G
0 1 - - - - - - - - - - - - - - - - - - G - T - - - EUR-350 G
0 1 - - - - - - - - - - - - - - - - - - G - - - A - EUR-350 G
1 0 - - - - - - - - - - - - G - - - - - G - - - - - EUR-350 G
0 1 - - - - T - - - - - - - - - A G - T G - - - - - NA (non-EUR)
1 1 - - C G T - - - - - - - - - A G - T - - - - - - AFR1 (non-EUR)
0 1 - G - G T - - - - - - - - - A G G T G - - - - - AFR1 (non-EUR)
2 1 C - T G T - - - - - - - - - A G - T - G - - - - AFR2 (non-EUR)
1 0 C - T G T - C - - - - - - - A G - T - G - - - - AFR2 (non-EUR)
0 1 C - T G T - - - - - - - - G A G - T - G - - - - AFR2 (non-EUR)
0 1 - - - G T - - - A T T - - - A G G T - - - - - - AFR2 (non-EUR)
1 0 - - - G T - - - - - - - - - A G - T - - - - - - AFR2 (non-EUR)
56 86                          
  1. Sequence results are shown by outcome of infection: *Clearance (HPV16-negative at follow-up visit between 4–16 months) or *Persistence (HPV16-positive at follow-up visit between 4–16 months).
  2. Abbreviations: EUR EURopean, NA North American, AFR AFRican.
  3. 0 = failed sequencing for the whole E6 gene, a shorter fragment of E6 was determined (nt. 256–400).