Figure 1

Mutation in exon 6 of the p53 gene in the HIV group compared with the control group. Panel a: Electrophoretic analysis of cervical p53 gene mutations using PCR-Single Strand Conformational Polymorphism (PCR-SSCP) in an 8% polyacrylamide gel stained with ethidium bromide. Samples A1-A3, negative for p53 gene mutations; A4, positive for p53 gene mutation (arrow); C, negative control p 53 reactions; M, 25 bp molecular weight marker. Panel b: The frequency of mutations in p53 exons 5 to 8 in both groups. Exon 7 and exon 6 were the most mutated exons examined in the HIV group and in the control group, respectively.