Figure 1

Diagram of LMP-1 structural and functional motifs. Cytoplasmic terminal activating regions are labeled CTAR1-3 and labeled with their corresponding amino acid numbers. The region that we sequenced is labeled, along with the positions of amino acid mutations in the K variant sequence, designated with *. The 10 amino acid deletion associated with NPC is labeled with X. The T cell epitope region of CTAR3 is labeled TCE, the JAK3 binding region is labeled JAK3, and the TRADD motif of CTAR2 is labeled TRADD.