Characterization of the EBV genome sequence derived from whole-genome deep sequencing of NPC cell line C666-1. (a) Circos plot demonstrates the genome-wide comparison of SNVs and indels in EBV genome of C666-1 (green bars) and those of other reported strains (HKNPC1, red bars; GD2, orange bars; GD1, blue bars; AG876, grey bars). The WT-EBV genome sequence was used as reference. (b) Summary of SNVs and indels identified in C666-1 strain. (c) Phylogenetic analysis of the genome sequences in five EBV strains, C666-1, HKNPC1, GD1, GD2, AG876 and EBV-WT. (d) A nonsense mutation in codon 333 (Q to stop) of BNRF1 identified in the C666-1 strain. The wild type sequence from the NPC xenograft xeno-2117 is also shown.