Figure 4

Specimens of bladder urothelium. A = non-neoplastic urothelium with no nuclear expression for p21 from HCV-infected patients, B = Transitional cell carcinoma (TCC) with nuclear immunoreactivity for p21 in more than 10% of tumor cells from non-HCV infected patients and C = lost p21 expression in most tumor cells from HCV infected patients (Immunoperoxidase DAB X 400).