Skip to main content

Table 3 Genotypes’ association with HPV status and test for deviation from Hardy-Weinberg Equilibrium

From: HPV prevalence and genetic predisposition to cervical cancer in Saudi Arabia

Gene, genotype and allele HPV+/− n( %) Odds ratio P-Value Deviation from HWE
Cases Controls (95% CI)   Expected
(HPV+) (n= 82) (HPV-) (n= 18) Cases Controls
XRCC1 codon 399 G>A Arg/Gln (rs25487)
Genotype       
G/G 42 (51) 11 (61)    37.56 10.89
G/A 27 (33) 6 (33) 1.18 (0.39-3.56) 0.77 35.87 6.22
A/A 13 (16) 1 (6) 3.41 (0.40-28.93) 0.24 8.56 0.89
G/A+A/A 40 (49) 7 (39) 1.49 (0.53-4.24) 0.45   
Allele       
G 111 (68) 28 (78)     
A 53 (32) 8 (22) 1.67 (0.71-3.91) 0.23   
Armitages’ trend test Common OR= 1.67 0.28   
Significance level (P-value) for deviation from HWE 0.03 0.88
TP53 (p53) codon 72 G>C Arg/Pro (rs1042522)
Genotype       
G/G 18 (22) 2 (11)    22.03 2.35
G/C 49 (60) 9 (50) 0.61 (0.12-3.07) 0.54 40.95 8.31
C/C 15 (18) 7 (39) 0.24 (0.04-1.32) 0.08 19.03 7.35
G/C+C/C 64 (78) 9 (89) 0.44 (0.09-2.12) 0.29   
Allele       
G 85 (52) 13 (36)     
C 79 (48) 23 (64) 0.53 (0.25-1.11) 0.09   
Armitages’ trend test: Common OR= 0.48 0.06   
Significance level (P-value) for deviation from HWE 0.07 0.72
  1. HWE: Hardy-Weinberg Equilibrium. OR: Odds Ratio.
  2. Computed online at: http://ihg.gsf.de/cgi-bin/hw/hwa1.pl.