Table 2 Genotypes’ and alleles’ frequencies of 7 assessed polymorphisms in 100 cervix carcinoma patients in addition to 100 age-and-gender matched control volunteers without cancers
From: HPV prevalence and genetic predisposition to cervical cancer in Saudi Arabia
Gene, genotype and allele | Cancer patients’ frequency | Normal volunteers’ frequency | Odds ratio | P- Value |
|---|---|---|---|---|
(95% CI) | Â | |||
(%, n= 100) | (%, n= 100) | |||
CDKN1A (p21) codon 31 C>A Ser/Arg rs1801270 | ||||
C/C | 64 (64) | 62 (62) | Â | Â |
C/A | 32 (32) | 35 (35) | 0.89 (0.49-1.60) | 0.69 |
A/A | 4 (4) | 3 (3) | 1.29 (0.28-6.01) | 0.74 |
C | 160 (80) | 159 (79) | Â | Â |
A | 40 (20) | 41 (21) | 0.97 (0.59-1.58) | 0.90 |
TP53 (p53) codon 72 G>C Arg/Pro rs1042522 | ||||
G/G | 20 (20) | 22 (22) | Â | Â |
G/C | 58 (58) | 52 (52) | 1.23 (0.60-2.50) | 0.57 |
C/C | 22 (22) | 26 (26) | 0.93 (0.41-2.14) | 0.87 |
G | 98 (49) | 96 (48) | Â | Â |
C | 102 (51) | 104 (52) | 0.96 (0.65-1.42) | 0.84 |
ATM codon 1853 G>A Asp/Asn rs1801516 | ||||
G/G | 90 (90) | 88 (88) | Â | Â |
G/A | 8 (8) | 12 (12) | 0.65 (0.25-1.67) | 0.37 |
A/A | 2 (2) | 0 (0) | 4.89 (0.23-103.2) | 0.16 |
G | 188 (94) | 188 (94) | Â | Â |
A | 12 (6) | 12 (6) | 1.00 (0.44-2.28) | 1 |
HDM2 promoter 309 T>C rs2279744 | ||||
T/T | 30 (30) | 27 (27) | Â | Â |
T/C | 46 (46) | 44 (44) | 0.94 (0.48-1.83) | 0.86 |
C/C | 24 (24) | 29 (29) | 0.75 (0.35-1.58) | 0.44 |
T | 106 (53) | 98 (49) | Â | Â |
C | 94 (47) | 102 (51) | 0.85 (0.58-126) | 0.42 |
TGFβ1 codon 10 T>C Leu/Pro rs1982073 | ||||
T/T | 48 (48) | 39 (39) | Â | Â |
T/C | 31 (31) | 38 (38) | 0.89 (0.42-1.91) | 0.77 |
C/C | 21 (21) | 23 (23) | 1.35 (0.65-2.79) | 0.42 |
T | 127 (64) | 116 (58) | Â | Â |
C | 73 (37) | 84 (42) | 1.26 (0.84-1.88) | 0.26 |
XRCC1 codon 399 G>A Arg/Gln rs25487 | ||||
G/G | 52 (52) | 59 (59) | Â | Â |
G/A | 34 (34) | 40 (40) | 0.96 (0.54-1.74) | 0.90 |
A/A | 14 (14) | 1 (1) | 15.88 (2.0-124.9)) | 0.0007 |
G | 138 (69) | 158 (79) | Â | Â |
A | 62 (31) | 42 (21) | 1.69 (1.07-2.66) | 0.02 |
XRCC3 codon 241 C>T Thr/Met rs861539 | ||||
C/C | 45 (45) | 41 (41) | Â | Â |
C/T | 44 (44) | 37 (37) | 1.08 (0.59-1.99) | 0.79 |
T/T | 11 (11) | 22 (22) | 0.46 (0.20-1.05) | 0.06 |
C | 134 (67) | 119 (60) | Â | Â |
T | 66 (33) | 81 (41) | 0.72 (0.48-1.09) | 0.12 |