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Table 2 Genotypes’ and alleles’ frequencies of 7 assessed polymorphisms in 100 cervix carcinoma patients in addition to 100 age-and-gender matched control volunteers without cancers

From: HPV prevalence and genetic predisposition to cervical cancer in Saudi Arabia

Gene, genotype and allele Cancer patients’ frequency Normal volunteers’ frequency Odds ratio P- Value
(95% CI)  
(%, n= 100) (%, n= 100)
CDKN1A (p21) codon 31 C>A Ser/Arg rs1801270
C/C 64 (64) 62 (62)   
C/A 32 (32) 35 (35) 0.89 (0.49-1.60) 0.69
A/A 4 (4) 3 (3) 1.29 (0.28-6.01) 0.74
C 160 (80) 159 (79)   
A 40 (20) 41 (21) 0.97 (0.59-1.58) 0.90
TP53 (p53) codon 72 G>C Arg/Pro rs1042522
G/G 20 (20) 22 (22)   
G/C 58 (58) 52 (52) 1.23 (0.60-2.50) 0.57
C/C 22 (22) 26 (26) 0.93 (0.41-2.14) 0.87
G 98 (49) 96 (48)   
C 102 (51) 104 (52) 0.96 (0.65-1.42) 0.84
ATM codon 1853 G>A Asp/Asn rs1801516
G/G 90 (90) 88 (88)   
G/A 8 (8) 12 (12) 0.65 (0.25-1.67) 0.37
A/A 2 (2) 0 (0) 4.89 (0.23-103.2) 0.16
G 188 (94) 188 (94)   
A 12 (6) 12 (6) 1.00 (0.44-2.28) 1
HDM2 promoter 309 T>C rs2279744
T/T 30 (30) 27 (27)   
T/C 46 (46) 44 (44) 0.94 (0.48-1.83) 0.86
C/C 24 (24) 29 (29) 0.75 (0.35-1.58) 0.44
T 106 (53) 98 (49)   
C 94 (47) 102 (51) 0.85 (0.58-126) 0.42
TGFβ1 codon 10 T>C Leu/Pro rs1982073
T/T 48 (48) 39 (39)   
T/C 31 (31) 38 (38) 0.89 (0.42-1.91) 0.77
C/C 21 (21) 23 (23) 1.35 (0.65-2.79) 0.42
T 127 (64) 116 (58)   
C 73 (37) 84 (42) 1.26 (0.84-1.88) 0.26
XRCC1 codon 399 G>A Arg/Gln rs25487
G/G 52 (52) 59 (59)   
G/A 34 (34) 40 (40) 0.96 (0.54-1.74) 0.90
A/A 14 (14) 1 (1) 15.88 (2.0-124.9)) 0.0007
G 138 (69) 158 (79)   
A 62 (31) 42 (21) 1.69 (1.07-2.66) 0.02
XRCC3 codon 241 C>T Thr/Met rs861539
C/C 45 (45) 41 (41)   
C/T 44 (44) 37 (37) 1.08 (0.59-1.99) 0.79
T/T 11 (11) 22 (22) 0.46 (0.20-1.05) 0.06
C 134 (67) 119 (60)   
T 66 (33) 81 (41) 0.72 (0.48-1.09) 0.12