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Table 1 Activating KIRs and Kir/HLA receptor/ligand genotypes distribution in 32 classic Kaposi Sarcoma (cKSpos), and in 51 cKSneg (18 KSHV-infected plus 33 KSHV-uninfected) individuals

From: Activating KIR/HLA complexes in classic Kaposi's Sarcoma

KIR/KIR-ligands

cKSpos

cKSneg

P value

OR (95%CI)

 

N/T %

N/T %

  

2DS1+

21/32 (65.6)

17/51 (33.3)

p y = 0.008

3.82 (1.4-10.9)

2DS1+/C2+

17/26 (65.4)

12/39 (30.7)

p y = 0.01

4.25 (1.3-14.2)

2DS1+/C2-

4/6 (66.7)

5/12 (41.7)

pf = 0.62

ND

2DS2+

27/32 (84.4)

31/51 (60.8)

p y = 0.04

3.48 (1.0-12.3)

2DS2+/C1+

18/22 (81.8)

21/38 (56.7)

p y = 0.09

3.43 (0.9-14.9)

2DS2+/C1-

9/10 (90.0)

10/14 (71.4)

pf = 0.36

ND

3DS1+

20/32 (62.5)

15/51 (29.4)

p y = 0.006

4.00 (1.4-11.4)

3DS1+/Bw4+

11/18 (61.1)

10/32 (31.2)

py = 0.08

3.46 (0.9-13.9)

3DS1+/Bw4*80I+

6/11 (54.5)

7/19 (36.8)

py = 0.45

2.06 (0.4-12.3)

3DS1+/Bw4-

9/14 (64.3)

5/19 (26.3)

py = 0.68

5.04 (0.9-30.6)

3DS1+/Bw4*80I-

14/21 (66.6)

8/32 (25.0)

p y = 0.006

6.00 (1.5-24.6)

HLA C2+

26/32 (81.2)

39/51 (76.5)

py = 0.80

1.33 (0.4-4.6)

HLA C1+

22/32 (68.7)

37/51 (72.5)

py = 0.90

0.83 (0.3-2.4)

HLA Bw4

18/32 (56.3)

32/51 (62.7)

py = 0.72

0.76 (0.3-2.1)

HLA Bw4*80I+

11/32 (34.4)

19/51 (37.5)

py = 0.97

0.88 (0.3-2.5)

  1. N/T: Number of subjects/Total subjects; (%) percentage in brackets;: py = p value with Yate's correction,: pf = p value calculated with fisher exact test for small number; OR: Odds ratio, IC: Interval of confidence
  2. HLA C2 + (C2/C2; C2/C1), HLA C1 + (C1/C1; C2/C1), HLA Bw4 (Bw4+/Bw4+, Bw4+/Bw4-)
  3. HLA Bw4*80I+ (Bw4*80I+/Bw4*80I+, Bw4*80I+/*Bw4*80I-)
  4. The statistically significant associations are marked in bold