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Figure 4 | Infectious Agents and Cancer

Figure 4

From: Evaluation of a combined triple method to detect causative HPV in oral and oropharyngeal squamous cell carcinomas: p16 Immunohistochemistry, Consensus PCR HPV-DNA, and In Situ Hybridization

Figure 4

HR HPV ISH in Head and Neck squamous cell carcinomas. Note the clear nuclear staining with tetrazole blue as punctuate signals and clusters, corresponding to integration and episomic status respectively A, B) Control cases of cervical HSIL. C) Integration and episomal clusters are uniformly distributed in tonsil cancer (OPSCC) harboring type 16 HPV-DNA; note integrative punctuate signals and cluster spot throughout the entire tumor. D) Heterogeneous integration signals in oral cancer harboring type 16 HPV-DNA. (In situ hybridization; tetrazole blue signals stain the viral DNA; nuclear counterstaining with fast red; original magnifications a, b, ×10; c, ×40; d ×60).

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