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Figure 3 | Infectious Agents and Cancer

Figure 3

From: Evaluation of a combined triple method to detect causative HPV in oral and oropharyngeal squamous cell carcinomas: p16 Immunohistochemistry, Consensus PCR HPV-DNA, and In Situ Hybridization

Figure 3

The role of CDKN2a promoter methylation in p16 down-regulation. A) Percentage of CDKN2a promoter methylation in OSCC and in oral epithelia exposed to alcohol and tobacco risk factors. B) Representative examples of Methylation-Specific PCR (MSP) for CDKN2a/INK4a locus (p16) in OSCC. Legend. K, cancer samples; N, normal samples; M, CDKN2a methylated; U, CDKN2a unmethylated.

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