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Figure 1 | Infectious Agents and Cancer

Figure 1

From: Evaluation of a combined triple method to detect causative HPV in oral and oropharyngeal squamous cell carcinomas: p16 Immunohistochemistry, Consensus PCR HPV-DNA, and In Situ Hybridization

Figure 1

IHC expression of p16 protein in representative HPV positive (DNA type 16) and HPV negative OSCCs. P16 is expressed only at basal-parabasal levels in epithelium surrounding OSCC, whereas it is over-expressed in OSCC. The figure in the middle page depicted p16 expression according different HR and LR-HPVs. The figure in the bottom represent a p16 negative OSCC; the p16 under-expression is due to promoter methylation od CDKN2a. Legend. K, cancer samples; M, CDKN2a methylated; U, CDKN2a unmethylated.

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Infectious Agents and Cancer

ISSN: 1750-9378

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