Toll-like receptor 3 in Epstein-Barr virus-associated nasopharyngeal carcinomas: consistent expression and cytotoxic effects of its synthetic ligand poly(A:U) combined to a Smac-mimetic

Table 1 Detection of the TLR3 protein by immunohistochemistry on tissue sections from NPC biopsies

Patient N°	Origin	Gender/age	Clinical stage	TLR3 staining
Patient N°	Origin	Gender/age	Clinical stage	Distribution	Intensity
1	Tunisia	M/48	T4N3bM1	Homogeneous	Faint
2	Romania	F/34	T2bN0M0	Heterogeneous	Moderate
3	Cameroon	M/62	T4N2M0	Heterogeneous	Moderate
4	France	M/63	T4N0Mx	Homogeneous	Strong
5	France	M/62	T3N2M0	Heterogeneous	Strong
6	Portugal	F/84	T4N2M0	Heterogeneous	Strong
7	Algeria	M/40	T4N2M0	Homogeneous	Faint
8	Turkey	M/57	T1N0M0	Homogeneous	Moderate
9	China	F/31	T4N0M0	Homogeneous	Moderate
10	France	M/48	T1N2M0	Homogeneous	Faint

All specimens were of the non-keratinizing undifferentiated histologic subtype of the WHO classification (2005).
Images for cases 6 and 8 are displayed in Figure2.
M0 indicates absence of extranodal metastases; M1, presence of extranodal metastases at the time of diagnosis; Mx, no assessment of distant metastases.

ISSN: 1750-9378