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Figure 5 | Infectious Agents and Cancer

Figure 5

From: Toll-like receptor 3 in Epstein-Barr virus-associated nasopharyngeal carcinomas: consistent expression and cytotoxic effects of its synthetic ligand poly(A:U) combined to a Smac-mimetic

Figure 5

Synergistic inhibition of NPC cells clonogenic growth by combination of poly(A:U) with a Smac-mimetic. NPC cells and NP69 cells were treated with poly(A:U) (0.25 μg/mL for C666-1, 0.5 μg/mL for HONE1, 1 μg/mL for CNE1 and NP69) used either alone or in combination with RMT5265 (5 nM for C666-1 and HONE1, 30 nM for CNE1 and NP69). A feeder of irradiated Normal Human Dermal Fibroblasts (NHDF) was used for C666-1 clonogenic assays as described in the Materials and Methods section. (A) A representative aspect of the results of the clonogenic assays is displayed in the upper panel. (B) The percentage of inhibition was calculated based on the number of colonies, and the excess over Bliss additivism (EOBA) confirmed the synergic effects of the therapeutic combinations on NPC cells. The results are given as mean +/− SD

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Infectious Agents and Cancer

ISSN: 1750-9378

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