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Table 3 Association analysis of SNPs (−592, -819, -1082, -1352) in the promoter region of the IL-10 gene, in Squamous Intraepithelial Cervical Lesions (SICL)
| (−592 C/A) (rs1800872) | (−819 C/T) (rs1800871) | ||||||
|---|---|---|---|---|---|---|---|
| Genotype | n(%)SICL/(%)NCL (n = 204/166) | ORa (IC95%) | p Value* | Genotype | n(%)SICL/(%)NCL (n = 204/166) | ORa (IC95%) | p Value* |
| Codominant Model | Codominant Model | ||||||
| C/C | 50(24.5)/66(40) | 1 | C/C | 64(31.4)/57(34.3) | 1 | ||
| C/A | 105(52)/70(42) | 2.0(1.21-3.32) | 0.007 | C/T | 94(46)/75(45.2) | 1.16(0.71-1.92) | 0.53 |
| A/A | 49(24)/30(18) | 2.07(1.10-3.89) | 0.02 | T/T | 46(22.6)/34(20.5) | 1.15(0.62-2.12) | 0.64 |
| Dominant Model | Dominant Model | ||||||
| C/C | 50(24.5)/66(40) | 1 | C/C | 64(31.4)/57(34.3) | 1 | ||
| C/A + A/A | 154(76)/100(60) | 2.02(1.26-3.25) | 0.003 | C/T + T/T | 140(68.5)/109(65.7) | 1.16(0.73-1.84) | 0.51 |
| Recessive Model | Recessive Model | ||||||
| C/C + C/A | 155(76)/136(82) | 1 | C/C + C/T | 158(77.4)/132(79.5) | 1 | ||
| A/A | 49(24)/30(18) | 1.37(0.79-2.39) | 0.25 | T/T | 46(22.6)/34(20.5) | 1.05(0.61-1.81) | 0.84 |
| Alleles | Alleles | ||||||
| C | 205(51)/202(60) | 1 | C | 222(54)/189(57) | 1 | ||
| A | 203(49)/130(40) | 1.32 (0.97-1.81) | 0.07 | T | 186(46)/143(43) | 1.10(0.80-1.50) | 0.53 |
| p HWE** | 0.13 | p HWE** | 0.31 | ||||
| (−1082 A/G) (rs1800872) | (−1352 G/A) (rs1800893) | ||||||
| Genotype | n(%)SICL/(%)NCL (n = 204/166) | OR a (IC95%) | p Value* | Genotype | n(%)SICL/(%)NCL (n = 204/166) | OR a (IC95%) | p Value* |
| Codominant Model | Codominant Model | ||||||
| A/A | 125(61.3)/92(55.4) | 1 | G/G | 130(63.72)/102(61.44) | 1 | ||
| A/G | 66(32.3)/62(37.3) | 0.95(0.59-1.52) | 0.84 | G/A | 64(31.37)/53(31.94) | 1.28(0.78-2.07) | 0.31 |
| G/G | 13(6.4/12(7.3) | 1.02(0.42-2.44) | 0.96 | A/A | 10(4.9)/11(6.62) | 0.85(0.33-2.22) | 0.75 |
| Dominant Model | Dominant Model | ||||||
| A/A | 125(61.3)/92(55.4) | 1 | G/G | 130(63.72)/102(61.44) | 1 | ||
| A/G + G/G | 79(38.7)/74(44.6) | 0.96(0.61-1.50) | 0.87 | G/A + A/A | 74(36.27)/64(38.56) | 1.20(0.76-1.90) | 0.42 |
| Recessive Model | Recessive Model | ||||||
| A/A + A/G | 191(93.6)/154(92.7) | 1 | G/G + G/A | 194(95)/155(93.38) | 1 | ||
| G/G | 13(6.4/12(7.3) | 1.04(0.44-2.44) | 0.92 | A/A | 10(4.9)/11(6.62) | 0.78(0.30-1.99) | 0.6 |
| Alleles | Alleles | ||||||
| A | 316(77)/246(74) | 1 | G | 324(79)/257(77) | 1 | ||
| G | 92(23)/86(26) | 1.01(0.71-1.45) | 0.92 | A | 84(21)/75(23) | 1.08(0.74-1.58) | 0.65 |
| p HWE** | 0.72 | p HWE** | 0.26 | ||||
