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Table 3 Association analysis of SNPs (−592, -819, -1082, -1352) in the promoter region of the IL-10 gene, in Squamous Intraepithelial Cervical Lesions (SICL)

From: The SNP at −592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development

(−592 C/A) (rs1800872) (−819 C/T) (rs1800871)
Genotype n(%)SICL/(%)NCL (n = 204/166) ORa (IC95%) p Value* Genotype n(%)SICL/(%)NCL (n = 204/166) ORa (IC95%) p Value*
Codominant Model Codominant Model
C/C 50(24.5)/66(40) 1 C/C 64(31.4)/57(34.3) 1
C/A 105(52)/70(42) 2.0(1.21-3.32) 0.007 C/T 94(46)/75(45.2) 1.16(0.71-1.92) 0.53
A/A 49(24)/30(18) 2.07(1.10-3.89) 0.02 T/T 46(22.6)/34(20.5) 1.15(0.62-2.12) 0.64
Dominant Model Dominant Model
C/C 50(24.5)/66(40) 1 C/C 64(31.4)/57(34.3) 1
C/A + A/A 154(76)/100(60) 2.02(1.26-3.25) 0.003 C/T + T/T 140(68.5)/109(65.7) 1.16(0.73-1.84) 0.51
Recessive Model Recessive Model
C/C + C/A 155(76)/136(82) 1 C/C + C/T 158(77.4)/132(79.5) 1
A/A 49(24)/30(18) 1.37(0.79-2.39) 0.25 T/T 46(22.6)/34(20.5) 1.05(0.61-1.81) 0.84
Alleles Alleles
C 205(51)/202(60) 1 C 222(54)/189(57) 1
A 203(49)/130(40) 1.32 (0.97-1.81) 0.07 T 186(46)/143(43) 1.10(0.80-1.50) 0.53
p HWE** 0.13 p HWE** 0.31
(−1082 A/G) (rs1800872) (−1352 G/A) (rs1800893)
Genotype n(%)SICL/(%)NCL (n = 204/166) OR a (IC95%) p Value* Genotype n(%)SICL/(%)NCL (n = 204/166) OR a (IC95%) p Value*
Codominant Model Codominant Model
A/A 125(61.3)/92(55.4) 1 G/G 130(63.72)/102(61.44) 1
A/G 66(32.3)/62(37.3) 0.95(0.59-1.52) 0.84 G/A 64(31.37)/53(31.94) 1.28(0.78-2.07) 0.31
G/G 13(6.4/12(7.3) 1.02(0.42-2.44) 0.96 A/A 10(4.9)/11(6.62) 0.85(0.33-2.22) 0.75
Dominant Model Dominant Model
A/A 125(61.3)/92(55.4) 1 G/G 130(63.72)/102(61.44) 1
A/G + G/G 79(38.7)/74(44.6) 0.96(0.61-1.50) 0.87 G/A + A/A 74(36.27)/64(38.56) 1.20(0.76-1.90) 0.42
Recessive Model Recessive Model
A/A + A/G 191(93.6)/154(92.7) 1 G/G + G/A 194(95)/155(93.38) 1
G/G 13(6.4/12(7.3) 1.04(0.44-2.44) 0.92 A/A 10(4.9)/11(6.62) 0.78(0.30-1.99) 0.6
Alleles Alleles
A 316(77)/246(74) 1 G 324(79)/257(77) 1
G 92(23)/86(26) 1.01(0.71-1.45) 0.92 A 84(21)/75(23) 1.08(0.74-1.58) 0.65
p HWE** 0.72 p HWE** 0.26
  1. a. Odds ratio adjusted by age and HPV genotype.
  2. ** Hardy-Weinberg Equilibrium in controls (NCL).
  3. *p Value < = 0.01 adjusted by Bonferroni.
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Infectious Agents and Cancer

ISSN: 1750-9378

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