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Table 3 Association analysis of SNPs (−592, -819, -1082, -1352) in the promoter region of the IL-10 gene, in Squamous Intraepithelial Cervical Lesions (SICL)

From: The SNP at −592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development

(−592 C/A) (rs1800872)

(−819 C/T) (rs1800871)

Genotype

n(%)SICL/(%)NCL (n = 204/166)

ORa (IC95%)

p Value*

Genotype

n(%)SICL/(%)NCL (n = 204/166)

ORa (IC95%)

p Value*

Codominant Model

Codominant Model

C/C

50(24.5)/66(40)

1

C/C

64(31.4)/57(34.3)

1

C/A

105(52)/70(42)

2.0(1.21-3.32)

0.007

C/T

94(46)/75(45.2)

1.16(0.71-1.92)

0.53

A/A

49(24)/30(18)

2.07(1.10-3.89)

0.02

T/T

46(22.6)/34(20.5)

1.15(0.62-2.12)

0.64

Dominant Model

Dominant Model

C/C

50(24.5)/66(40)

1

C/C

64(31.4)/57(34.3)

1

C/A + A/A

154(76)/100(60)

2.02(1.26-3.25)

0.003

C/T + T/T

140(68.5)/109(65.7)

1.16(0.73-1.84)

0.51

Recessive Model

Recessive Model

C/C + C/A

155(76)/136(82)

1

C/C + C/T

158(77.4)/132(79.5)

1

A/A

49(24)/30(18)

1.37(0.79-2.39)

0.25

T/T

46(22.6)/34(20.5)

1.05(0.61-1.81)

0.84

Alleles

Alleles

C

205(51)/202(60)

1

C

222(54)/189(57)

1

A

203(49)/130(40)

1.32 (0.97-1.81)

0.07

T

186(46)/143(43)

1.10(0.80-1.50)

0.53

p HWE**

0.13

p HWE**

0.31

(−1082 A/G) (rs1800872)

(−1352 G/A) (rs1800893)

Genotype

n(%)SICL/(%)NCL (n = 204/166)

OR a (IC95%)

p Value*

Genotype

n(%)SICL/(%)NCL (n = 204/166)

OR a (IC95%)

p Value*

Codominant Model

Codominant Model

A/A

125(61.3)/92(55.4)

1

G/G

130(63.72)/102(61.44)

1

A/G

66(32.3)/62(37.3)

0.95(0.59-1.52)

0.84

G/A

64(31.37)/53(31.94)

1.28(0.78-2.07)

0.31

G/G

13(6.4/12(7.3)

1.02(0.42-2.44)

0.96

A/A

10(4.9)/11(6.62)

0.85(0.33-2.22)

0.75

Dominant Model

Dominant Model

A/A

125(61.3)/92(55.4)

1

G/G

130(63.72)/102(61.44)

1

A/G + G/G

79(38.7)/74(44.6)

0.96(0.61-1.50)

0.87

G/A + A/A

74(36.27)/64(38.56)

1.20(0.76-1.90)

0.42

Recessive Model

Recessive Model

A/A + A/G

191(93.6)/154(92.7)

1

G/G + G/A

194(95)/155(93.38)

1

G/G

13(6.4/12(7.3)

1.04(0.44-2.44)

0.92

A/A

10(4.9)/11(6.62)

0.78(0.30-1.99)

0.6

Alleles

Alleles

A

316(77)/246(74)

1

G

324(79)/257(77)

1

G

92(23)/86(26)

1.01(0.71-1.45)

0.92

A

84(21)/75(23)

1.08(0.74-1.58)

0.65

p HWE**

0.72

p HWE**

0.26

  1. a. Odds ratio adjusted by age and HPV genotype.
  2. ** Hardy-Weinberg Equilibrium in controls (NCL).
  3. *p Value < = 0.01 adjusted by Bonferroni.