Figure 1

Hepatitis B virus X protein (HBx). A) Schematic representation of HBx domain organization. As shown, HBx is functionally organized into an N-terminal, and a C-terminal domain. The N-terminal third of HBx corresponds to the negative regulatory domain, which includes a Ser/Pro-rich region. The remaining C-terminal two-thirds of the protein comprises the transactivation domain. B) Multiple sequence alignment of HBx proteins from all main HBV genotypes using ClustalW. Accession numbers are indicated in the left column, followed by the HBV genotype of each isolate. Conserved Ser, Thr, and Tyr residues are shown in bold across the sequences. At the bottom of the alignment, the consensus sequence is marked by an asterisk, conserved substitutions by a double dot, and a semiconserved substitution by a single dot.