Table 4 HPV types 16/18 and HPV types 16/18/45 by histotype, study and year of diagnosis
From: HPV type distribution in invasive cervical cancers in Italy: pooled analysis of three large studies
|  | 1999° | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | All years | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histological type | ||||||||||||
 Squamous cell carcinoma | 16/18 (n) | 16 | 23 | 30 | 34 | 56 | 60 | 62 | 62 | 13 | 9 | 365 |
% | 64,0 | 74,2 | 73,2 | 66,7 | 73,7 | 76,9 | 75,6 | 89,9 | 81,3 | 81,8 | 75,9 | |
16/18/45 (n) | 18 | 24 | 30 | 37 | 64 | 65 | 68 | 63 | 14 | 9 | 392 | |
% | 72,0 | 77,4 | 73,2 | 72,5 | 84,2 | 83,3 | 82,9 | 91,3 | 87,5 | 81,8 | 81,5 | |
| Â | Any type (n) | 26 | 31 | 41 | 51 | 76 | 78 | 82 | 69 | 16 | 11 | 481 |
Adeno- and Adeno-squamous cell carcinoma | 16/18 (n) | 0 | 2 | 1 | 3 | 6 | 5 | 9 | 10 | 7 | 0 | 43 |
% | - | 50,0 | 50,0 | 75,0 | 85,7 | 100,0 | 75 | 83,3 | 70 | - | 76,8 | |
16/18/45 (n) | 0 | 2 | 2 | 4 | 6 | 5 | 11 | 11 | 8 | 0 | 49 | |
% | - | 50,0 | 100,0 | 100,0 | 85,7 | 100,0 | 91,7 | 91,7 | 80 | - | 87,5 | |
| Â | Any type (n) | 0 | 4 | 2 | 4 | 7 | 5 | 12 | 12 | 10 | 0 | 56 |
Study | ||||||||||||
 Milan Study | 16/18 (n) | 11 | 20 | 19 | 22 | 28 | 24 | 33 | 29 | 1 | 0 | 187 |
% | 61,1 | 71,4 | 70,4 | 71,0 | 68,3 | 85,7 | 82,5 | 85,3 | 100,0 | - | 75,1 | |
16/18/45 (n) | 12 | 21 | 19 | 23 | 32 | 24 | 36 | 31 | 1 | 0 | 199 | |
% | 66,7 | 75,0 | 70,4 | 74,2 | 78,0 | 85,7 | 90,0 | 91,2 | 100,0 | - | 79,9 | |
| Â | Any type (n) | 19 | 28 | 27 | 31 | 41 | 28 | 40 | 34 | 1 | 0 | 249 |
 Rome Study | 16/18 (n) | 0 | 0 | 7 | 8 | 16 | 22 | 16 | 11 | 0 | 0 | 80 |
% | - | - | 100,0 | 50,0 | 76,2 | 71,0 | 66,7 | 84,6 | - | - | 71,4 | |
16/18/45 (n) | 0 | 0 | 7 | 10 | 17 | 24 | 17 | 11 | 0 | 0 | 86 | |
% | - | - | 100,0 | 62,5 | 81,0 | 77,4 | 70,8 | 84,6 | - | - | 76,8 | |
| Â | Any type (n) | 0 | 0 | 7 | 16 | 21 | 31 | 24 | 13 | 0 | 0 | 112 |
 Central and Southern Italy Study | 16/18 (n) | 5 | 5 | 5 | 7 | 18 | 19 | 22 | 32 | 19 | 9 | 134 |
% | 71,4 | 71,4 | 55,6 | 87,5 | 85,7 | 79,2 | 73,3 | 94,1 | 76,0 | 81,8 | 76,1 | |
16/18/45 (n) | 6 | 5 | 6 | 8 | 21 | 22 | 26 | 32 | 21 | 9 | 156 | |
% | 85,7 | 71,4 | 66,7 | 100,0 | 100,0 | 91,7 | 86,7 | 94,1 | 84,0 | 81,8 | 88,6 | |
| Â | Any type (n) | 7 | 7 | 9 | 8 | 21 | 24 | 30 | 34 | 25 | 11 | 176 |
Total Squamous cell carcinoma | 16/18 (n) | 16 | 25 | 31 | 37 | 65 | 66 | 72 | 72 | 20 | 9 | 413 |
% | 64,0 | 74,2 | 73,2 | 66,7 | 73,7 | 76,9 | 75,6 | 89,9 | 81,3 | 81,8 | 75,9 | |
16/18/45 (n) | 18 | 26 | 32 | 41 | 73 | 71 | 80 | 74 | 22 | 9 | 446 | |
% | 72,0 | 77,4 | 73,2 | 72,5 | 84,2 | 83,3 | 82,9 | 91,3 | 87,5 | 81,8 | 81,5 | |
| Â | Any type (n) | 26 | 35 | 43 | 55 | 86 | 84 | 95 | 81 | 26 | 11 | 542 |