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Table 3 NLRP3 and NLRP1 allele, genotype and haplotypes frequencies in mesothelioma patients exposed and not exposed to asbestos (MMAE vs MMAF)

From: NLRP1 polymorphisms in patients with asbestos-associated mesothelioma

  

MMAE (N=69)

MMAF (n=65)

p

OR (95% CI)

NLRP3 rs35829419

Allele/ Genotype

    
 

A

7 (0.05)

3 (0.02)

  
 

C

131 (0.95)

127 (0.98)

0.337

0.44 0.07-1.99

 

A/A

0

0

  
 

C/A

7 (0.10)

3 (0.05)

  
 

C/C

62 (0.90)

62 (0.95)

0.327

 

NLRP3 rs10754558

Allele/ Genotype

    
 

G

58 (0.42)

56 (0.43)

  
 

C

80 (0.58)

74 (0.57)

0.902

1.04 0.62-1.74

 

G/G

11 (0.16)

12 (0.19)

  
 

C/G

36 (0.53)

32 (0.47)

  
 

C/C

22 (0.31)

21 (0.34)

0.946

 

rs35829419-rs10754558

Haplotypes

    
 

C-C

80 (0.58)

73 (0.56)

0.453

 
 

C-G

51 (0.37)

53 (0.41)

  
 

A-G

7 (0.05)

3 (0.01)

  

NLRP1 rs2670660

Allele/ genotype

    
 

A

62 (0.45)

70 (0.54)

  
 

G

76 (0.55)

60 (0.46)

0.179

1.43 0.86-2.40

 

A/A

12 (0.18)

21 (0.32)

  
 

A/G

38 (0.54)

28 (0.44)

  
 

G/G

19 (0.28)

16 (0.24)

0.138

 

NLRP1 rs12150220

Allele/ genotype

    
 

A

62 (0.45)

71 (0.55)

  
 

T

76 (0.55)

59 (0.45)

0.142

1.47 0.89-2.46

 

A/A

11 (0.16)

20 (0.31)

  
 

A/T

41 (0.59)

31 (0.48)

  
 

T/T

17 (0.25)

14 (0.22)

0.146

 

rs2670660-rs12150220

Haplotypes

    
 

A.A

51 (0.40)

53 (0.41)

0.919

 
 

G-T

63 (0.50)

62 (0.48)

  
 

G-A

6 (0.05)

9 (0.07)

  
 

A-T

6 (0.05)

6 (0.05)