Table 2 NLRP3 and NLRP1 allele, genotype and haplotypes frequencies in mesothelioma patients and controls exposed to asbestos (MMAE vs HCAE)
From: NLRP1 polymorphisms in patients with asbestos-associated mesothelioma
MMAE (N=69) | HCAE (n=101) | p | OR (95% CI) | ||
|---|---|---|---|---|---|
NLRP3 rs35829419 | Allele/ Genotype | ||||
A | 7 (0.05) | 10 (0.05) | |||
C | 131 (0.95) | 192 (0.95) | 1 | 0.97 0.32-3.10 | |
A/A | 0 | 0 | |||
C/A | 7 (0.10) | 10 (0.09) | |||
C/C | 62 (0.90) | 91 (0.91) | 1 | ||
NLRP3 rs10754558 | Allele/ Genotype | ||||
G | 58 (0.42) | 82 (0.41) | |||
C | 80 (0.58) | 120 (0.59) | 0.823 | 0.94 0.59-1.50 | |
G/G | 11 (0.16) | 13 (0.13) | |||
C/G | 36 (0.53) | 56 (0.55) | |||
C/C | 22 (0.31) | 32 (0.32) | 0.842 | ||
rs35829419-rs10754558 | Haplotypes | ||||
C-C | 80 (0.58) | 119 (0.59) | 0.908 | ||
C-G | 51 (0.37) | 75 (0.37) | |||
A-G | 7 (0.05) | 8 (0.04) | |||
NLRP1 rs2670660 | Allele genotype | ||||
A | 62 (0.45) | 116 (0.57) | |||
G | 76 (0.55) | 86 (0.43) | 0.027 | 1.65 1.04-2.62 | |
A/A | 12 (0.18) | 30 (0.30) | |||
A/G | 38 (0.54) | 56 (0.55) | |||
G/G | 19 (0.28) | 15 (0.15) | 0.059 | ||
NLRP1 rs12150220 | Allele/ genotype | ||||
A | 62 (0.45) | 120 (0.59) | |||
T | 76 (0.55) | 82 (0.41) | 0.011 | 1.79 1.13-2.85 | |
A/A | 11 (0.16) | 32 (0.32) | |||
A/T | 41 (0.59) | 56 (0.55) | |||
T/T | 17 (0.25) | 13 (0.13) | 0.027 | ||
T/T (A/T+A/A) | 0.065 | 2.20 0.92-5.37 | |||
(T/T+A/T) A/A | 0.030 | 2.43 1.08-5.84 | |||
rs2670660-rs12150220 | Haplotypes | ||||
A-A* | 51 (0.40) | 114 (0.56) | 0.006 *0.004 | *0.52 *(0.33-0.83) | |
G-T | 63 (0.50) | 80 (0.40) | |||
G-A | 6 (0.05) | 6 (0.03) | |||
A-T | 6 (0.05) | 2 (0.01) |