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Table 7 Odds ratios (OR) and 95% confidence intervals (CI) for squamous cell carcinoma and adenocarcinoma of the cervix according to HIV infection and adjustment factors: age, CD4 count (decrease of 100 cells), and human papillomavirus (HPV) types

From: HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda: a case-control study

 

Squamous cell carcinoma

N = 246 cases, 308 controlsa

Adenocarcinoma

N = 39 cases, 308 controlsb

Adjustment factor

OR for HIV-positive vs. HIV-negative

95% CI

OR for HIV-positive vs. HIV-negative

95% CI

Age

1.5

0.9-2.3

1.1

0.4-2.7

Age + CD4

1.6

1.0-2.6

0.8

0.1-2.6

Age + CD4 + HPV16

1.6

0.9-2.9

0.5

0.1-1.8

Age + CD4 + HPV16-relatedc

1.4

0.7-2.4

0.5

0.1-1.6

Age + CD4 + HPV18

1.4

0.8-2.4

0.3

<1.2j

Age + CD4 + HPV18-relatedd

1.4

0.8-2.4

0.4

0.1-1.5

Age + CD4 + High-risk HPVe

0.6

0.3-1.1

0.3

<0.9j

Age + CD4 + Low-risk HPVf

1.9

1.1-3.2

0.8

0.2-2.6

Age + CD4 + Single HPV inf.g

1.2

0.6-2.4

0.5

0.1-1.7

Age + CD4 + Multiple HPV inf.h

1.8

1.1-3.0

0.6

0.1-2.0

Age + CD4 + Any HPV inf.i

0.8

0.4-1.4

0.4

0.1-1.2

  1. a HIV-positive: 48 cases, 54 controls.
  2. b HIV-positive: 5 cases, 54 controls.
  3. c HPV16-related: includes HPV16, 31, 33, 35, 52 and 58.
  4. d HPV18-related: includes HPV18, 45, 59 and 68.
  5. e High-risk HPV: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73.
  6. f Low-risk HPV: 6, 11, 34, 40, 42, 43, 44, 53, 54, 66, 70, 74.
  7. g Single infection: infection with any of the HPV types above.
  8. h Multiple infections: infections with at least two different HPV types.
  9. i Any HPV infection: infection with any of the HPV types above.
  10. j Indicate only lower limit value of 95% CI.
  11. Abbreviations: inf: infections,.