HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda: a case-control study

Table 5 Risk of adenocarcinoma of the cervix for different human papillomavirus (HPV) types^a

HPV type	Number HPV-positive		Age adjusted		Age and HIV adjusted		Age, HIV and CD4 adjusted
	Cases	Controls	OR	95% CI	OR	95% CI	OR	95% CI
High-risk HPV
All^b	26	54	27.2	10.4-88.9	40.5	14.1-157.4	40.0	13.9-155.6
16	10	10	11.6	4.3-31.8	14.5	5.2-42.6	13.8	4.9-40.2
18	10	8	18.5	6.6-54.4	26.3	8.3-96.5	24.0	7.7-86.9
31	1	3	2.2	0.2-16.1	2.6	0.2-19.6	2.6	0.2-19.2
33	0	5	1.2	<12.2^j	1.4	<14.6^j	1.3	<14.1^j
35	0	7	0.8	<7.1^j	0.9	<8.3^j	0.8	<7.9^j
39	0	1	5.5	<108.6^j	4.7	<92.5^j	4.7	<92.5^j
45	4	0	297.4	>26.4^k	248.3	>22.1^k	247.8	>22.0^k
51	2	8	3.9	0.7-16.9	4.1	0.7-17.6	4.1	0.7-17.7
52	0	13	0.3	<2.4^j	0.4	<3.4^j	0.3	<2.9^j
56	0	4	0.8	<11.0	1.0	<12.1^j	1.0	<12.8^j
58	0	3	1.3	<15.5^j	1.3	<14.9^j	1.3	<14.9^j
59	0	2	0.9	<18.6^j	1.1	<19.27^j	1.1	<19.8^j
68/73	2	7	3.0	0.5-13.7	3.6	0.6-16.2	3.4	0.6-16.0
Low-risk HPV
All^c	1	24	0.6	0.1-2.4	0.6	0.1-2.7	0.6	0.1-2.6
6	1	3	12.8	1.1-96.7	10.0	0.9-76.0	10.0	0.9-75.9
11	0	2	3.7	<55.1^j	4.6	<64.5^j	3.8	<56.5^j
34	0	1	4.3	<82.4^j	6.4	<161^j	4.6	<126.4^j
40	0	1	5.3	<102.7^j	4.5	<88.3^j	4.5	<88.3^j
44	1	4	5.4	0.5-35.2	4.8	0.4-30.3	4.8	0.4-30.3
53	0	4	0.7	<7.6^j	0.8	<8.7^j	0.8	<8.3^j
54	0	3	0.6	<7.4^j	0.7	<8.0^j	0.7	<8.0^j
66	0	5	0.9	<9.0^j	1.2	<12.7^j	1.0	<11.2^j
70	0	3	1.3	<15.3^j	1.6	<17.7^j	1.4	<16.0^j
74	0	4	0.8	<11.1^j	0.9	<11.9^j	0.9	<11.5^j
Single inf.^d	22	49	13.7	6.0-34.0	15.5	6.6-40.5	15.3	6.5-40.0
Multiple inf.^e	4	20	2.5	0.7-7.5	3.3	0.9-10.5	3.1	0.8-9.8
16-related^f	11	36	3.6	1.5-8.2	4.9	2.0-11.6	4.7	1.9-11.2
18-related^g	16	16	22.8	9.3-58.9	26.2	10.3-71.8	24.5	9.7-67.0
HPVX^h	0	26	0.2	<1.2^b	0.2	<1.3^b	0.2	<1.5^b
Any HPVⁱ	26	95	12.9	5.0-41.8	18.7	6.6-71.6	18.6	6.6-71.2

^a Analysis conducted with 32 cases and 309 controls.
^b High-risk HPV: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73.
^c Low-risk HPV: 6, 11, 34, 40, 42, 43, 44, 53, 54, 66, 70, 74.
^d Single infection: infection with any of the HPV types above, except HPVX.
^e Multiple infections: infections with at least two different HPV types, except HPVX.
^f HPV16-related: includes HPV16, 31, 33, 35, 52 and 58.
^g HPV18-related: includes HPV18, 45, 59 and 68.
^h HPVX: Samples which could not be typed with any of the 25 genotypes above.
ⁱ Any HPV infection: infection with any of the HPV types above.
^j Indicate only upper limit value of 95% CI.
^k Indicate only lower limit value of 95% CI.
Abbreviations: inf: infections, OR: odds ratio, CI: confidence interval.

ISSN: 1750-9378