HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda: a case-control study

Table 3 Risk^a of squamous cell carcinoma of the cervix for different human papillomavirus (HPV) types

HPV type	HPV-positive		Age adjusted N = 203 cases & 309 controls		Age and HIV adjusted N = 193 cases & 303 controls		Age, HIV and CD4 adjusted N = 192 cases & 296 controls
	Cases	Controls	OR	95% CI	OR	95% CI	OR	95% CI
High-risk HPV
All^b	183	54	64.5	35.4-126.6	84.7	43.5-181.6	82.3	42.2-176.8
16	101	10	29.1	15.4-60.7	28.8	15.2-60.2	27.2	14.4-56.9
18	39	8	9.6	4.6-22.3	8.9	4.2-20.6	8.3	4.0-19.2
31	2	3	0.8	0.1-4.6	0.7	0.1-3.7	0.5	0.1-2.8
33	4	5	1.3	0.3-4.7	1.2	0.3-4.4	1.4	0.3-5.6
35	10	7	2.4	0.9-6.7	2.5	0.9-6.9	2.7	1.0-8.1
39	3	1	3.7	0.6-38.9	4.2	0.7-44.4	4.2	0.7-44.2
45	18	0	58.7	>7.9^j	56.5	>7.6^j	57.2	>7.7^j
51	2	8	0.8	0.2-2.7	0.5	0.1-2.1	0.5	0.1-2.1
52	6	13	0.7	0.2-1.7	0.6	0.2-1.5	0.5	0.2-1.3
56	2	4	0.9	0.2-4.6	1.0	0.2-4.7	1.1	0.2-5.5
58	2	3	0.9	0.2-5.1	1.0	0.2-5.8	1.1	0.2-5.8
59	1	2	0.7	0.1-6.5	0.8	0.1-7.4	0.8	0.1-7.4
68/73	6	7	1.5	0.5-4.6	1.3	0.4-4.0	1.3	0.4-3.9
Low-risk HPV
All^c	5	24	0.5	0.2-1.0	0.3	0.1-0.8	0.3	0.1-0.7
6	1	3	1.0	0.1-7.0	1.1	0.1-8.0	1.1	0.1-7.9
11	0	2	0.5	<6.4^k	0.4	<5.4^k	0.3	<4.3^k
34	0	1	0.6	<11.1^k	0.4	<7.5^k	0.3	<5.3^k
40	0	1	0.7	<13.0^k	0.8	<14.7^k	0.8	<14.6^k
42	1	0	4.1	>0.2^j	^l	^l	^l	^l
44	0	4	0.2	<2.2^k	0.3	<2.5^k	0.2	<2.5^k
53	0	4	0.1	<1.2^k	0.1	<1.2^k	0.1	<1.1^k
54	1	3	0.4	<2.5^k	0.4	<2.8^k	0.5	<2.9^k
66	0	5	0.4	<2.2^k	0.1	<1.0^k	0.1	<1.1^k
70	1	3	0.7	0.1-4.2	0.6	0.1-3.7	0.5	0.1-3.2
74	2	4	1.0	0.1-4.2	0.9	0.2-4.6	0.8	0.1-3.8
Single inf.^d	168	49	33.3	20.2-56.7	31.5	19.1-54.0	31.0	18.7-53.5
Multiple inf.^e	15	20	1.3	0.7-2.7	1.2	0.6-2.4	1.1	0.5-2.3
16-related^f	123	36	11.6	7.5-18.5	11.9	7.6-19.0	11.4	7.2-18.3
18-related^g	66	16	9.4	5.3-17.4	8.9	5.0-16.5	8.6	4.9-16.1
HPVX^h	3	26	0.2	0.1-0.5	0.2	0.1-0.5	0.2	0.1-0.6
Any HPVⁱ	186	95	50.8	25.8-113.9	55.7	27.2-132.4	54.9	26.7-130.4

^a OR and 95% CI.
^b High-risk HPV: 16, 18, 31, 33, 35, 45, 51, 52, 56, 58, 59, 68/73.
^c Low-risk HPV: 6, 11, 34, 40, 42, 43, 44, 53, 54, 66, 70, 74.
^d Single infection: infection with any of the HPV types above, except HPVX.
^e Multiple infections: infections with at least two different HPV types, except HPVX.
^f HPV16-related: includes HPV16, 31, 33, 35, 52 and 58.
^g HPV18-related: includes HPV18, 45, 59 and 68.
^h HPVX: Samples which could not be typed with any of the 25 genotypes above.
ⁱ Any HPV infection: infection with any of the HPV types above.
^j Indicate only lower limit value of 95% CI.
^k Indicate only upper limit value of 95% CI.
^l Could not be estimated due to lack of cases with known HIV status.
Abbreviations: inf: infections, OR: odds ratio, CI: confidence interval.

ISSN: 1750-9378