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Table 4 Unadjusted and age-adjusted associations (hazard ratio) between Wave 1 HHV-8 seropositivity and prostate cancer at Wave 2 or Wave 3, overall and within strata defined by Wave 1 prostate cancer screening test results

From: A case-cohort study of human herpesvirus 8 seropositivity and incident prostate cancer in Tobago

Wave 1 prostate cancer screening test result Cases Sub-cohort Unadjusted Age-adjusted
  Pos n Pos n HR 95% CI HR 95% CI
Overall 17 96 46 415 1.46 0.78-2.74 0.881 0.46-1.69
PSA (ng/mL)         
   < 4 12 70 39 392 1.61 0.77-3.38 1.031 0.49-2.16
   ≥ 4 5 26 7 23 0.44 0.11-1.71 0.392 0.10-1.63
DRE positive or PSA ≥ 4 ng/mL         
   no 9 54 32 345 1.67 0.72-3.86 1.021 0.44-2.39
   yes 8 42 14 70 0.85 0.52-2.38 0.593 0.18-1.91
  1. Pos - number HHV-8 positive, n - case or sub-cohort count, HR - hazard ratio, CI - confidence interval, PSA - prostate-specific antigen, DRE - digital rectal examination
  2. 1. Adjusted across four age categories: 40-44, 45-49, 50-59, ≥ 60 years
  3. 2. Adjusted across two age categories: 40-59, ≥ 60 years
  4. 3. Adjusted across three age categories: 40-49, 50-59, ≥ 60 years