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Table 1 Comparison of clinico-pathological parameters in HPV- DNA (group I) and HPV16+ DNA (group II) oral squamous cell carcinomas

From: Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with HPV16 E7 oncoprotein

Parameters

Group I

(HPV-)

(%)

n.39

Group II

(HPV16+)

(%)

n.23

p

value*

Age at diagnosis, year

     

   < 53

(10)

4

(4)

1

 

   53-73

(54)

21

(70)

16

 

   > 73

(36)

14

(26)

6

N.S

Sex

     

   Female

(46)

18

(43)

10

 

   Male

(54)

21

(57)

13

N.S.

Site of primary tumor

     

   Tongue

(46)

18

(48)

11

 

   Buccal Mucosa

(26)

10

(22)

5

 

   Alveolar Ridge Mucosa

(18)

7

(17)

4

 

   Palate

(10)

4

(13)

3

N.S.

Tumor Histological Grade

     

   Well (G1)

(57)

22

(65)

15

 

   Moderate (G2)

(28)

11

(26)

6

 

   Poor (G3)

(15)

6

(9)

2

N.S.

TNM Stage

     

   I

(64)

25

(22)

5

 

   II

(8)

3

(44)

10

 

   III

(13)

5

(30)

7

 

   IV

(15)

6

(4)

1

< .001

pT

     

   1

(64)

25

(22)

5

 

   2

(10)

4

(48)

11

 

   3

(10)

4

(26)

6

 

   4

(16)

6

(4)

1

< .001

  1. * Chi-square test and Fisher's exact test; statistical results were considered significant for p values < .05 (N.S. indicates not significant)