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Table 3 HPV prevalence and genotype distribution among invasive cervical cancer cases

From: Epidemiology of HPV genotypes in Uganda and the role of the current preventive vaccines: A systematic review

Author Area, subjects Study design HPV test HPV prevalence for any and specific genotypes among all tested womena Comments
Schmauz et al., 1989 [55] Mulago hospital, cervical tissues from 34 cases and 23 controls Case Control Southern Blot analysis Casesa
HPV 16/18, 50%
HPV 16, 15%
HPV 18, 35%
Controlsa
HPV 18, 4.4%
Prevalence of HIV a
Cases, 5.9%
Controls, 21.7%
Odds of cervical cancer
HPV 18 (OR* = 12.0)
HPV16/18 (OR* = 22.0)
Odida et al., 2008 [56] Mulago, Pathology Department 186 paraffin embedded histologically confirmed archival cervical cancer cases
Collected 1968-69, 1970-79, and 1980-89.
Case series SPF10/LIPA Any HPVa, 61.3%
Type-specific genotypes a
HPV 16/18, 73.5%
HPV 16, 44.7%
HPV 18, 28.8%
HPV 45, 9.6%
Types
146 Squamous cell carcinoma
35 adenocarcinoma
3 Adenosquamous
2 undifferentiated types
Odida et al., 2010 [57] Mulago Hospital, Kampala, 171 pairs of paraffin embedded and freshly frozen tissue samples collected between September 2004 and December 2006 Case series SPF10/LIPA Any HPVa, Frozen tissue, 90.1%
Type-specific genotypes a
HPV 16, 47.4%
HPV 18, 19.5%
HPV 45, 9.7%
HPV 51, 1.9%
HPV 52, 1.3%
Any HPVa, Paraffin embedded tissue, 88.9%
Type-specific genotypes a
HPV 16, 47.4%
HPV 18, 23.7%
HPV 45, 7.9%
HPV 51, 1.3%
HPV 52, 1.3%
Multiple HPV genotypesa
Frozen tissue, 7.1%
Paraffin embedded, 4.6%
Single HPV genotypesa
Frozen tissue, 92.9% (95% CI: 87.6-96.4)
Paraffin embedded, 94.7% (95% CI: 89.9-97.7)
  1. a Denominator consist of all the tested women
  2. CI = Confidence Interval
  3. OR* = Odds Ratio