Table 3 HPV prevalence and genotype distribution among invasive cervical cancer cases

Schmauz et al., 1989 [55]

Mulago hospital, cervical tissues from 34 cases and 23 controls

Case Control

Southern Blot analysis

Cases^a

HPV 16/18, 50%

HPV 16, 15%

HPV 18, 35%

Controls^a

HPV 18, 4.4%

Prevalence of HIV ^a

Cases, 5.9%

Controls, 21.7%

Odds of cervical cancer

HPV 18 (OR* = 12.0)

HPV16/18 (OR* = 22.0)

Odida et al., 2008 [56]

Mulago, Pathology Department 186 paraffin embedded histologically confirmed archival cervical cancer cases

Collected 1968-69, 1970-79, and 1980-89.

Case series

SPF₁₀/LIPA

Any HPV^a, 61.3%

Type-specific genotypes ^a

HPV 16/18, 73.5%

HPV 16, 44.7%

HPV 18, 28.8%

HPV 45, 9.6%

Types

146 Squamous cell carcinoma

35 adenocarcinoma

3 Adenosquamous

2 undifferentiated types

Odida et al., 2010 [57]

Mulago Hospital, Kampala, 171 pairs of paraffin embedded and freshly frozen tissue samples collected between September 2004 and December 2006

Case series

SPF₁₀/LIPA

Any HPV^a, Frozen tissue, 90.1%

Type-specific genotypes ^a

HPV 16, 47.4%

HPV 18, 19.5%

HPV 45, 9.7%

HPV 51, 1.9%

HPV 52, 1.3%

Any HPV^a, Paraffin embedded tissue, 88.9%

Type-specific genotypes ^a

HPV 16, 47.4%

HPV 18, 23.7%

HPV 45, 7.9%

HPV 51, 1.3%

HPV 52, 1.3%

Multiple HPV genotypes^a

Frozen tissue, 7.1%

Paraffin embedded, 4.6%

Single HPV genotypes^a

Frozen tissue, 92.9% (95% CI^†: 87.6-96.4)

Paraffin embedded, 94.7% (95% CI^†: 89.9-97.7)