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Table 2 HPV types in clinical samples

From: Single-tube multiplex PCR using type-specific E6/E7 primers and capillary electrophoresis genotypes 21 human papillomaviruses in neoplasia

     

LR-HPV

HR-HPV

 

N

β-globin

HR-HPV

(%)

> 1

genotype

(%)

6

11

16

18

26

31

33

35

39

45

51

52

53

56

58

59

66

68

70

73

82

Cervical cytology

                         

normal

37

37

9 (24%)

3 (8%)

1

0

1

2

0

0

0

0

1

0

0

1

0

3

1

0

1

2

1

0

0

ASCUS1

12

12

6 (50%)

3 (25%)

0

0

0

3

0

0

1

0

1

3

1

1

0

0

0

0

0

0

0

0

1

columnar atypia

1

1

1 (100%)

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

CIN 1

24

24

18 (78%)

6 (25%)

2

0

4

2

0

2

3

1

1

2

2

1

0

1

1

2

1

1

1

2

0

CIN 2

11

11

11 (100%)

4 (36%)

0

0

7

3

0

2

2

0

0

0

0

0

0

0

1

0

1

0

0

0

1

CIN 3

4

4

4 (100%)

2 (50%)

0

0

3

0

0

1

0

0

0

1

0

0

1

0

1

1

1

0

0

1

0

SCC2

9

9

9 (100%)

3 (33%)

0

0

3

1

0

2

2

0

0

1

0

2

0

1

1

1

1

0

0

0

0

subtotal

98

98

58

21

3

0

18

12

0

7

8

1

3

7

3

5

1

5

5

4

5

3

2

3

2

FFPE

                         

CIN NOS

11

5

11 (100%)

2 (18%)

1

0

3

2

0

1

0

0

1

0

1

1

1

0

0

0

0

0

0

1

0

SCC, cervix

23

13

23 (100%)

2 (9%)

0

0

14

2

0

2

0

0

0

1

0

0

0

2

0

1

0

0

0

0

0

ADCA, cervix

10

5

9 (90%)

1 (10%)

0

0

5

3

0

0

0

0

0

1

0

0

0

0

0

1

1

0

0

0

0

subtotal

44

23

43

5

1

0

22

7

0

3

0

0

1

2

1

1

1

2

0

2

1

0

0

1

0

FTA

                         

SCC3

23

23

22 (96%)

1 (4%)4

1

1

14

1

0

1

1

1

0

2

0

1

1

1

1

0

0

0

1

1

0

ADCA5

11

11

11 (100%)

1 (9%)

0

0

5

4

0

2

0

0

0

0

0

0

0

0

0

1

0

0

0

0

0

SCC neck metastasis

316

31

10 (100%)7

0

0

0

9

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

subtotal

65

65

44

2

1

1

28

5

1

3

1

1

0

2

0

1

1

1

1

1

0

0

1

0

0

total

207

186

145

29

5

1

68

24

1

13

9

2

4

11

4

7

3

8

6

7

6

3

3

5

2

  1. 1 Atypical squamous cells of undetermined significance.
  2. 2 One bronchoalveolar lavage for a HPV59+ SCC metastasis from cervix cancer is included.
  3. 3 Includes 5 FTA imprints from consecutively resected cervical SCC (3 primary, 2 metastatic nodes) and 18 consecutive surface tumors swabbed in vivo.
  4. 4 Both low-risk HPV types 6 and 11 E6/E7 were present in a cervical SCC from an elderly woman.
  5. 5 Includes 6 FTA imprints from consecutively excised tumors (5 primary, 1 metastatic node) and 5 consecutive ADCA swabbed in vivo.
  6. 6 Primary tumors were located in the oropharynx (11), mesopharynx (2), nasopharynx (3), tongue (1), larynx (3), oral cavity (1), paranasal sinus (1), preauricular skin (3) and unknown sites (6).
  7. 7 HPV+ metastases were derived from 6 primary tumors in the oropharynx (5 tonsillar and 1 base of tongue) and 4 unknown sites. HPV26 was found in atypical squames in a neck node without a confirmed diagnosis of carcinoma but is included among SCC of unknown origin.