The use of high-dose azidothymidine in combination with chemotherapy upfront is an effective treatment approach for gamma-herpes virus-related non-Hodgkin’s lymphomas

Table 1 :

Age	Lymphoma type	Stage	PS	HIV	CD4	Alternating regimen	RT	Sustained Response (months)	Progression (months)	Death (months)
34	DLBCL	IVB	3	+	4	-	-	PD	1.0	1.3
49	BL	IVB	2	+	91	EPOCH	-	CR (50)	-	-
40	BL	IIA	2	-	-	hCVAD	+	CR (57)	-	-
51	DLBCL	IVB	2	+	47	EPOCH	-	CR (65)	-	-
40	BL	IVB	2	+	214	hCVAD	-	PD	2.0	-
34	PBL	IVB	2	+	16	-	-	PD	1.0	4.5
33	PBL	IIA	1	+	166	EPOCH	-	CR (18)	-	-
44	PBL	IVA	1	+	458	EPOCH	-	CR (19)	-	-
52	PBL	IIB	1	+	57	EPOCH	+	CR (20)	-	-
51	Solid PEL	IVB	2	+	113	-	-	CR (31), 2^nd CR (10)	After 1st line: 31.1	-

PS: ECOG performance score; RT: radiotherapy; DLBCL: diffuse large B-cell lymphoma; PEL: primary effusion lymphoma; PBL: plasmablastic lymphoma. EPOCH: etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin; hyper cVAD: dexamethasone and fractionated vincristine, doxorubicin cyclophosphamide; CR: complete remission; PR: partial remission; PD: progressive disease.

ISSN: 1750-9378