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Table 6 HAART and Incidence of Invasive Cervical Cancer

From: RTehvieew impact of antiretroviral therapy on HPV andcervical intraepithelial neoplasia: current evidence and directions for future research

Author

Outcome

Design

Results Comparison and reference groups

Association measures and CI

Conclusion

Intl Collaboration on HIV and Cancer 2000

Cases of ICC in multiple population studies

Meta-analysis

1997-1999 (post-HAART) vs. 1992-1996 (pre-HAART)

Adj IR 2.1 vs. 1.1; RR 1.87 (99% CI 0.77 - 4.56)

Higher incidence post HAART years, but not stats. significant

Dorucci et al 2001

Cases of ICC in Italian HIV Seroconversion Study

Prospective cohort/time-series analysis

1996-1998 (post-HAART) vs. 1981-1995 (pre-HAART)

IR 4.9 vs. 1.5; RH of Incidence 4.25 (0.8 - 28.24)

Higher incidence post HAART years, but not stats. significant

Clifford et al 2005

Cases of ICC from Swiss Cancer Registry

AIDS-Cancer Match Study

HAART vs. no HAART

SIR 0 vs. SIR 11.4; RR not estimatable

Unclear (incomplete reporting)

Engels et al 2006

Cases of ICC in HIV/AIDS Cancer Match Study

AIDS-Cancer Match Study

1996-2002 (post-HAART) vs. 1990-1995 (pre-HAART)

SIR 5.3 vs. SIR 4.2; RR pr year: 1.04 (95% CI: 0.94-1.15)

Higher incidence post HAART years, but not stats. significant

Biggar et al 2007

Cases of ICC in HIV/AIDS Cancer Match Study

AIDS-Cancer Match Study

1996-2002 (post-HART) vs. 1990-1995 (pre-HAART)

IR 86.5 vs. 64.2; RR of Incidence 1.41 (95% CI 0.81-2.46)

Higher incidence post HAART years, but not stats. significant

Engels et al 2008

Cases of ICC in HIV/AIDS Cancer Match Study

AIDS-Cancer Match Study

1996-2002 (post-HAART) vs. 1991-1995 (pre-HAART)

SIR 2.9 vs. 3.1; RR 0.8 (95% CI 0.3 - 2.0)

Lower incidence post HAART years, but not stats. significant

Dal Maso et al 2009

Cases of ICC in Italian Cancer Registries

AIDS-Cancer Match study

1997-2004 (post-HAART) vs. 1986-1996 (pre-HAART)

SIR 41.5 vs. 51.0; RR not reported

Lower incidence in post HAART years, but conclusion unclear (incomplete reporting)

  1. Foot note to tables: Abbreviations:
  2. ASCUS = atypical squamous cells of undetermined significance
  3. CD4+ = CD4+ T lymphocyte count (cells/mm3)
  4. DHHS = U.S. Department of Health and Human Services
  5. HAART = Highly active antiretroviral therapy
  6. HERS = HIV Epidemiology Research Study
  7. HIV = Human Immunodeficiency Virus
  8. HPV = Human papillomavirus
  9. HR = Hazard ratio
  10. HSIL = high-grade squamous intraepithelial lesions
  11. ICC = Invasive cervical cancer
  12. LSIL = low-grade squamous intraepithelial lesions
  13. NRTI = Nucleoside reverse transcriptase inhibitor
  14. NNRTI = Non-nucleoside reverse transcriptase inhibitor
  15. NR = Not reported
  16. OR = Odds ratio
  17. Pap = Papanicolaou smear
  18. PI = Protease inhibitor
  19. RR = Relative risk (rate ratio)
  20. SIR = Standardized incidence ratio
  21. WIHS = Women's Interagency HIV Study