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Table 6 HAART and Incidence of Invasive Cervical Cancer

From: RTehvieew impact of antiretroviral therapy on HPV andcervical intraepithelial neoplasia: current evidence and directions for future research

Author Outcome Design Results Comparison and reference groups Association measures and CI Conclusion
Intl Collaboration on HIV and Cancer 2000 Cases of ICC in multiple population studies Meta-analysis 1997-1999 (post-HAART) vs. 1992-1996 (pre-HAART) Adj IR 2.1 vs. 1.1; RR 1.87 (99% CI 0.77 - 4.56) Higher incidence post HAART years, but not stats. significant
Dorucci et al 2001 Cases of ICC in Italian HIV Seroconversion Study Prospective cohort/time-series analysis 1996-1998 (post-HAART) vs. 1981-1995 (pre-HAART) IR 4.9 vs. 1.5; RH of Incidence 4.25 (0.8 - 28.24) Higher incidence post HAART years, but not stats. significant
Clifford et al 2005 Cases of ICC from Swiss Cancer Registry AIDS-Cancer Match Study HAART vs. no HAART SIR 0 vs. SIR 11.4; RR not estimatable Unclear (incomplete reporting)
Engels et al 2006 Cases of ICC in HIV/AIDS Cancer Match Study AIDS-Cancer Match Study 1996-2002 (post-HAART) vs. 1990-1995 (pre-HAART) SIR 5.3 vs. SIR 4.2; RR pr year: 1.04 (95% CI: 0.94-1.15) Higher incidence post HAART years, but not stats. significant
Biggar et al 2007 Cases of ICC in HIV/AIDS Cancer Match Study AIDS-Cancer Match Study 1996-2002 (post-HART) vs. 1990-1995 (pre-HAART) IR 86.5 vs. 64.2; RR of Incidence 1.41 (95% CI 0.81-2.46) Higher incidence post HAART years, but not stats. significant
Engels et al 2008 Cases of ICC in HIV/AIDS Cancer Match Study AIDS-Cancer Match Study 1996-2002 (post-HAART) vs. 1991-1995 (pre-HAART) SIR 2.9 vs. 3.1; RR 0.8 (95% CI 0.3 - 2.0) Lower incidence post HAART years, but not stats. significant
Dal Maso et al 2009 Cases of ICC in Italian Cancer Registries AIDS-Cancer Match study 1997-2004 (post-HAART) vs. 1986-1996 (pre-HAART) SIR 41.5 vs. 51.0; RR not reported Lower incidence in post HAART years, but conclusion unclear (incomplete reporting)
  1. Foot note to tables: Abbreviations:
  2. ASCUS = atypical squamous cells of undetermined significance
  3. CD4+ = CD4+ T lymphocyte count (cells/mm3)
  4. DHHS = U.S. Department of Health and Human Services
  5. HAART = Highly active antiretroviral therapy
  6. HERS = HIV Epidemiology Research Study
  7. HIV = Human Immunodeficiency Virus
  8. HPV = Human papillomavirus
  9. HR = Hazard ratio
  10. HSIL = high-grade squamous intraepithelial lesions
  11. ICC = Invasive cervical cancer
  12. LSIL = low-grade squamous intraepithelial lesions
  13. NRTI = Nucleoside reverse transcriptase inhibitor
  14. NNRTI = Non-nucleoside reverse transcriptase inhibitor
  15. NR = Not reported
  16. OR = Odds ratio
  17. Pap = Papanicolaou smear
  18. PI = Protease inhibitor
  19. RR = Relative risk (rate ratio)
  20. SIR = Standardized incidence ratio
  21. WIHS = Women's Interagency HIV Study