Table 4 Summary of studies analyzing the impact of ART on progression of cervical disease among HIV-infected women

Orlando et al 1999

Pap result lower to higher grade lesions

6 months; 114 days (median)

CD4+ <200/mm³ vs. CD4+ ≥ 200/mm³ (all women on HAART)

OR 2.18 (95% CI and p-value not reported)

Unclear (incomplete reporting)

Schuman et al 2003

Pap result of LSIL, HSIL

4 years (median)

HAART vs. no ART

OR 1.5 (0.90 - 2.49), p 0.12

HAART has no impact on progression of SIL

Paramsothy et al 2009

Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL

2 years for women on HAART, 2.7 years not on HAART

HAART vs. no HAART

HR 0.7 (0.6 1.0), p >0.05

HAART has no impact on progression of SIL

Lillo et al 2001

Pap result: Normal to LSIL or HSIL and LSIL to HSIL

15.4 months (median)

HAART vs. no ART, adjusted for CD4+

OR 2.01 (0.44 - 9.20), p 0.36

HAART has no impact on progression of SIL

Del Mistro et al 2004

Pap result: "persistence or worsening"

49% followed for >3 years

HAART vs. no ART

19/36 (53%) women vs. 8/16 (50%) women, p NR

Unclear (incomplete reporting)

Minkoff et al 2001

Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL

6 months: consecutive paired results on each participant

HAART vs. no HAART, adjusted for CD4+ and initial Pap result

OR 0.68 (0.52-0.88), p NR

Only study showing evidence that HAART prevents progression of SIL