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Table 4 Summary of studies analyzing the impact of ART on progression of cervical disease among HIV-infected women

From: RTehvieew impact of antiretroviral therapy on HPV andcervical intraepithelial neoplasia: current evidence and directions for future research

Author Outcome Follow-up Results Comparison and reference groups Association (95% CI), p value Conclusion
Orlando et al 1999 Pap result lower to higher grade lesions 6 months; 114 days (median) CD4+ <200/mm3 vs. CD4+ ≥ 200/mm3 (all women on HAART) OR 2.18 (95% CI and p-value not reported) Unclear (incomplete reporting)
Schuman et al 2003 Pap result of LSIL, HSIL 4 years (median) HAART vs. no ART OR 1.5 (0.90 - 2.49), p 0.12 HAART has no impact on progression of SIL
Paramsothy et al 2009 Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL 2 years for women on HAART, 2.7 years not on HAART HAART vs. no HAART HR 0.7 (0.6 1.0), p >0.05 HAART has no impact on progression of SIL
Lillo et al 2001 Pap result: Normal to LSIL or HSIL and LSIL to HSIL 15.4 months (median) HAART vs. no ART, adjusted for CD4+ OR 2.01 (0.44 - 9.20), p 0.36 HAART has no impact on progression of SIL
Del Mistro et al 2004 Pap result: "persistence or worsening" 49% followed for >3 years HAART vs. no ART 19/36 (53%) women vs. 8/16 (50%) women, p NR Unclear (incomplete reporting)
Minkoff et al 2001 Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL 6 months: consecutive paired results on each participant HAART vs. no HAART, adjusted for CD4+ and initial Pap result OR 0.68 (0.52-0.88), p NR Only study showing evidence that HAART prevents progression of SIL