|
Orlando et al 1999
|
Pap result lower to higher grade lesions
|
6 months; 114 days (median)
|
CD4+ <200/mm3 vs. CD4+ ≥ 200/mm3 (all women on HAART)
|
OR 2.18 (95% CI and p-value not reported)
|
Unclear (incomplete reporting)
|
|
Schuman et al 2003
|
Pap result of LSIL, HSIL
|
4 years (median)
|
HAART vs. no ART
|
OR 1.5 (0.90 - 2.49), p 0.12
|
HAART has no impact on progression of SIL
|
|
Paramsothy et al 2009
|
Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL
|
2 years for women on HAART, 2.7 years not on HAART
|
HAART vs. no HAART
|
HR 0.7 (0.6 1.0), p >0.05
|
HAART has no impact on progression of SIL
|
|
Lillo et al 2001
|
Pap result: Normal to LSIL or HSIL and LSIL to HSIL
|
15.4 months (median)
|
HAART vs. no ART, adjusted for CD4+
|
OR 2.01 (0.44 - 9.20), p 0.36
|
HAART has no impact on progression of SIL
|
|
Del Mistro et al 2004
|
Pap result: "persistence or worsening"
|
49% followed for >3 years
|
HAART vs. no ART
|
19/36 (53%) women vs. 8/16 (50%) women, p NR
|
Unclear (incomplete reporting)
|
|
Minkoff et al 2001
|
Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL
|
6 months: consecutive paired results on each participant
|
HAART vs. no HAART, adjusted for CD4+ and initial Pap result
|
OR 0.68 (0.52-0.88), p NR
|
Only study showing evidence that HAART prevents progression of SIL
|
