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Table 3 Summary of studies analyzing the impact of ART on incidence of cervical disease among HIV-infected women

From: RTehvieew impact of antiretroviral therapy on HPV andcervical intraepithelial neoplasia: current evidence and directions for future research

Author Outcome Follow-up Results Comparison and reference groups Association (95% CI), p value Conclusion
Ellerbrock et al 2000 Histologically confirmed SIL cytology result 3-12 month period ARV therapy vs. no ARV therapy RR 1.0 (0.5 - 2.0), p 0.94 ART has no impact on incidence of SIL
Schuman et al 2003 Pap result of LSIL, HSIL 4 years (median) HAART vs. no HAART RR 1.2 (0.49 - 2.94), p 0.7 HAART has no impact on incidence of SIL
Heard et al 2006 Pap change from normal to LSIL or HSIL 28 months (median) HAART vs. no HAART RR 0.7 (0.4 - 1.2), p 0.15 HAART has no impact on incidence of SIL
Sirera et al 2007 Pap change from normal to LSIL or HSIL in all women on HAART Study period 1997 - 2005 CD4+ <200 cells/mm3 vs. >200 cells/mm3 (All participants on HAART) OR 0.38 (0.14 - 1.01), p 0.05 HAART has no impact on incidence of SIL
Sirera et al 2008 Pap change from normal to LSIL or HSIL Study period 1997 - 2006 HAART vs. no HAART OR 1.84 (0.72 - 4.69), p 0.20 HAART has no impact on incidence of SIL
Soncini et al 2007 Histologically confirmed CIN 11 years HAART vs. other NRTI or no ARV therapy, adjusted for CD4+ HR 0.3 (0.13 - 0.68), p 0.004 Only study showing HAART prevents incidence of CIN