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Table 4 Oncogenic viruses identified in each patient by IHC and ISH

From: Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients

Case # Diagnosis HPV EBV KSHV
   IHC ISH PCR IHC ISH PCR IHC ISH PCR
1 OSSN - - + + + + + + -
2 Pterygium + + + + + + + + +
3 OSSN + + + + - + + - +
4 OSSN + - + + + + + + +
5 OSSN + + + - + + + + -
6 OSSN + + + + + + + + +
8 OSSN + + + +/- +/- + - - +
9 OSSN + + + + + + + + -
11 OSSN + + + + + + + + +
12 OSSN + + + + + + + + +
13 OSSN -/+ -/+ -/+ + - + + + -
14 OSSN + + - + + - + - +
15 Pterygium + + - + + + + + +
16 Pterygium + + - + - + + + -
17 Pterygium + - - + + + + +/- +
18 OSSN + + - + + + + + +
19 OSSN + + - + + + + + +
21 OSSN + + - + + + + + +
22 OSSN + + - + + + + + -
23 OSSN + - - + + + + +/- +
24 OSSN + + - + + + + + +
25 Pterygium + +/- - + + + + + -
26 Pterygium + + + + + - + - +
27 Pterygium + + + + + + + + +
28 OSSN + +/- + + + + + + -
29 OSSN + + + + + - + + +
30 Pterygium + + + + + + + + -
31 OSSN + + + - - + +/- +/- +
32 OSSN - - - + + + + + -
33 OSSN + - + + + - + - +
34 OSSN - + + + + + + + +
35 OSSN + + + + + - + + +
36 OSSN + + + + - + + + -
37 OSSN - - + + + - + + +
38 OSSN + + + + + + + + +
39 OSSN + + + - - + + + +
  1. +/- Indeterminate
  2. Oncogenic viruses identified in each patient by Immunohistochemistry and In situ hybridization. It is noted that for each of the samples analyzed for the specific viruses-HPV-16/18, EBV, and KSHV, there was high concordance in IHC and ISH. For each virus a column for PCR results has been added for comparison. Due to lack of specimen we were unable to test for the other viruses. No tissue samples were available for patients 7, 10, and 20.