Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients

Table 4 Oncogenic viruses identified in each patient by IHC and ISH

Case #	Diagnosis	HPV			EBV			KSHV
		IHC	ISH	PCR	IHC	ISH	PCR	IHC	ISH	PCR
1	OSSN	-	-	+	+	+	+	+	+	-
2	Pterygium	+	+	+	+	+	+	+	+	+
3	OSSN	+	+	+	+	-	+	+	-	+
4	OSSN	+	-	+	+	+	+	+	+	+
5	OSSN	+	+	+	-	+	+	+	+	-
6	OSSN	+	+	+	+	+	+	+	+	+
8	OSSN	+	+	+	+/-	+/-	+	-	-	+
9	OSSN	+	+	+	+	+	+	+	+	-
11	OSSN	+	+	+	+	+	+	+	+	+
12	OSSN	+	+	+	+	+	+	+	+	+
13	OSSN	-/+	-/+	-/+	+	-	+	+	+	-
14	OSSN	+	+	-	+	+	-	+	-	+
15	Pterygium	+	+	-	+	+	+	+	+	+
16	Pterygium	+	+	-	+	-	+	+	+	-
17	Pterygium	+	-	-	+	+	+	+	+/-	+
18	OSSN	+	+	-	+	+	+	+	+	+
19	OSSN	+	+	-	+	+	+	+	+	+
21	OSSN	+	+	-	+	+	+	+	+	+
22	OSSN	+	+	-	+	+	+	+	+	-
23	OSSN	+	-	-	+	+	+	+	+/-	+
24	OSSN	+	+	-	+	+	+	+	+	+
25	Pterygium	+	+/-	-	+	+	+	+	+	-
26	Pterygium	+	+	+	+	+	-	+	-	+
27	Pterygium	+	+	+	+	+	+	+	+	+
28	OSSN	+	+/-	+	+	+	+	+	+	-
29	OSSN	+	+	+	+	+	-	+	+	+
30	Pterygium	+	+	+	+	+	+	+	+	-
31	OSSN	+	+	+	-	-	+	+/-	+/-	+
32	OSSN	-	-	-	+	+	+	+	+	-
33	OSSN	+	-	+	+	+	-	+	-	+
34	OSSN	-	+	+	+	+	+	+	+	+
35	OSSN	+	+	+	+	+	-	+	+	+
36	OSSN	+	+	+	+	-	+	+	+	-
37	OSSN	-	-	+	+	+	-	+	+	+
38	OSSN	+	+	+	+	+	+	+	+	+
39	OSSN	+	+	+	-	-	+	+	+	+

+/- Indeterminate
Oncogenic viruses identified in each patient by Immunohistochemistry and In situ hybridization. It is noted that for each of the samples analyzed for the specific viruses-HPV-16/18, EBV, and KSHV, there was high concordance in IHC and ISH. For each virus a column for PCR results has been added for comparison. Due to lack of specimen we were unable to test for the other viruses. No tissue samples were available for patients 7, 10, and 20.

ISSN: 1750-9378