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Table 1 Risk Factors and Pathologic Characteristics of HNC by p16, p53, and HPV Status for All Histologic and SCC1 Histologic Types

From: Human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer

Characteristics

p16-

p16+

All/SCC

p53+

p53-

All/SCC

HPV-

HPV-HR

All/SCC

 

N = 148

(%)

N = 89

(%)

p-value2

N = 114

(%)

N = 123

(%)

p-value2

N = 171

(%)

N = 66

(%)

p-value2

Gender

         

   Female

64 (43.2)

28 (31.5)

 

49 (43.0)

43 (35.0)

 

75 (43.9)

17 (25.8)

 

   Male

84 (56.8)

61 (68.5)

0.5/0.7

65 (57.0)

80 (65.0)

0.5

96 (56.1)

49 (74.2)

0.1/0.05

Age Group

         

   ≤ 55 years

48 (32.4)

41 (46.1)

0.2/0.2

37 (32.5)

52 (42.3)

0.4

58 (33.9)

31 (47.0)

0.6/0.4

   >55 years

100 (67.6)

48 (53.9)

 

77 (67.5)

71 (57.7)

 

113 (66.1)

35 (53.0)

 

Alcohol

         

   Never

45 (30.6)

22 (24.7)

 

31 (27.5)

36 (29.2)

 

55 (32.4)

12 (18.2)

 

   ≥ 1-21

58 (39.5)

39 (43.8)

0.9/0.2

45 (39.8)

52 (42.3)

0.6

66 (38.8)

31 (47.0)

0.06/0.002

   >21

44 (29.9)

28 (31.5)

0.8/0.4

37 (32.7)

35 (28.5)

0.3

49 (28.8)

23 (34.8)

0.08/0.02

Tobacco

         

   Never

34 (23.1)

19 (21.4)

 

26 (22.8)

27 (22.5)

 

45 (26.4)

8 (12.1)

 

   >0-30

38 (25.9)

27 (30.3)

0.2/0.4

32 (28.1)

33 (27.0)

0.7

37 (21.8)

28 (42.4)

0.001/0.007

   >30

75 (51.0)

43 (48.3)

0.9/0.3

56 (49.1)

62 (50.8)

0.97

88 (51.8)

30 (45.5)

0.3/0.8

p16 Status

         

   Positive

-

-

-

32 (28.1)

57 (46.3)

 

36 (21.1)

53 (80.3)

< 0.0001/

< 0.0001

   Negative

-

-

-

82 (71.9)

66 (53.7)

0.03

135 (78.9)

13 (19.7)

 

p53 Status

         

   Positive

82 (55.4)

32 (36.0)

0.03/0.02

-

-

-

88 (51.5)

26 (39.4)

0.99/0.9

   Negative

66 (44.6)

57 (64.0)

 

-

-

-

83 (48.5)

40 (60.6)

 

HPV Status

         

   HR

13 (08.8)

53 (59.6)

 

26 (22.8)

40 (32.5)

0.98

-

-

-

   Negative3

135 (91.2)

36 (40.4)

< .0001/< 0.001

88 (77.2)

83 (67.5)

 

-

-

-

Site

         

   Oropharynx

22 (14.9)

46 (51.7)

0.03/0.05

32 (28.1)

36 (29.3)

0.8

25 (14.6)

43 (65.2)

0.01/0.008

   Oral Cavity

99 (66.9)

38 (42.7)

0.3/0.4

63 (55.)

74 (60.1)

0.4

117 (68.4)

20 (30.3)

0.99/0.97

   Larynx/Hypo4

27 (18.2)

5 (5.6)

 

19 (16.7)

13 (10.6)

 

29 (17.0)

3 (4.5

 

Stage

         

   0/I/II

56 (38.1)

14 (15.7)

 

35 (30.7)

35 (28.7)

 

60 (35.3)

10 (15.2)

 

   III

25 (17.0)

17 (19.1)

0.2/0.2

20 (17.5)

22 (18.0)

0.6

28 (16.5)

14 (21.2)

0.2/0.4

   IV

66 (44.9)

58 (65.2)

0.02/0.01

59 (51.8)

65 (53.3)

0.5

82 (48.2)

42 (63.6)

0.2/0.6

Tumor Grade

         

   Well/Mod

118 (81.4)

55 (64.0)

 

87 (77.7)

86 (72.3)

 

132 (78.6)

41 (65.1)

 

   Poor/Undif5

27 (18.6)

31 (36.0)

0.06/0.02

25 (22.3)

33 (27.7)

0.7

36 (21.4)

22 (34.9)

0.6/0.7

Nodal Involvement

         

   Yes

59 (40.1)

61 (68.5)

0.04/0.04

53 (46.9)

67 (54.5)

0.9

73 (42.9)

47 (71.2)

0.05/0.2

   No

88 (59.9)

28 (31.5)

 

60 (53.1)

56 (45.5)

 

97 (57.1)

19 (28.8)

 

Histology

         

   SCC

138 (93.2)

77 (86.5)

0.08

106 (93.0)

109 (88.6)

0.2

152 (88.9)

63 95.4)

0.1

   nonSCC

10 (6.8)

12 (13.5)

 

8 (7.0)

14 (11.4)

 

19 (11.1)

3 (4.6)

 
  1. 1 SCC = squamous cell carcinoma; 2The left side of slash p-value is in reference to All histologies and the right side p-value refers to SCC only; the p-value is in reference to positive vs. negative biomarker status for each risk factor, p-values are adjusted for age, alcohol, tobacco, p16, p53, and HPV; 3 HPV negative (-) for all low-risk and high-risk HPV types; 4 Hypo = Hypopharynx; 5 Undif = Undifferentiated.
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Infectious Agents and Cancer

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