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Table 2 Risk of classical Kaposi sarcoma (cKS) or KS-associated herpesvirus (KSHV) seropositivity by Epstein Barr virus (EBV) antibody category

From: Risk of classical Kaposi sarcoma by plasma levels of Epstein-Barr virus antibodies, sCD26, sCD23 and sCD30

EBV antibody tertile category

Cases

N (%)

119

Seropositive controls

N (%)

105

ORadj* (95% CI)

HRadj** (95% CI)

Low EBNA-1

43 (36%)

34 (32%)

0.97 (0.52 - 1.82)

0.93 (0.45 -1.98)

High VCA

42 (35%)

45 (43%)

0.87 (0.45 - 1.69)

1.10 (0.50 - 2.35)

Low EBNA-1/high VCA

5 (4%)

6 (6%)

0.55 (0.15 - 2.00)

0.53 (0.12 - 2.29)

EBNA-1/VCA category

    

Low/High

Low/Not high

Not low/High

Not low/not high

5 (4%)

38 (32%)

37 (31%)

39 (33%)

6 (6%)

28 (27%)

39 (37%)

32 (30%)

0.56 (0.14 - 2.18)

1.08 (0.52 - 2.25)

0.98 (0.46 - 2.09)

Reference

0.62 (0.13 - 3.10)

1.20 (0.49 - 2.92)

1.23 (0.54 - 2.84)

Reference

EBV antibody tertile category

Seropositive controls

N (%)

105

Seronegative controls

N (%)

155

ORadj† (95% CI)

HRadj‡ (95% CI)

Low EBNA-1

34 (32%)

52 (34%)

0.98 (0.56 - 1.70)

1.04 (0.60 - 1.80)

High VCA

45 (43%)

42 (27%)

1.90 (1.04 - 3.47)

1.88 (1.04 - 3.40)

Low EBNA-1/high VCA

6 (6%)

6 (4%)

1.53 (0.47 -5.02)

1.00 (0.33 - 3.07)

EBNA-1/VCA category

    

Low/High

Not low/High

Low/Not high

Not low/not high

6 (6%)

28 (27%)

39 (37%)

32 (30%)

6 (4%)

46 (30%)

36 (23%)

67 (42%)

2.11 (0.61 - 7.30)

1.18 (0.61 - 2.27)

2.02 (1.00 - 4.07)

Reference

1.76 (0.52 - 5.93)

1.43 (0.74 - 2.78)

2.20 (1.14 - 4.24)

Reference

  1. * Adjusted odds ratio (ORadj) comparing cases to KHSV seropositive controls with logistic regression (adjusted for age group, sex, smoking, diabetes, cortisone use)
  2. ** Adjusted hazard ratio (HRadj) comparing cases to seropositive controls using conditional logistic regression (adjusted for age group, sex, smoking, diabetes and cortisone, and conditioning on assay batch)
  3. † Adjusted odds ratio (ORadj) comparing all tested KSHV seropositive controls to seronegative controls with logistic regression models (adjusted for matching factors: age group, sex, smoking and diabetes).
  4. ‡ Adjusted hazard ratio (HRadj) comparing matched KSHV seropositive and seronegative controls using conditional logistic regression (conditioning on matched set and assay batch).