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Table 2 Risk of classical Kaposi sarcoma (cKS) or KS-associated herpesvirus (KSHV) seropositivity by Epstein Barr virus (EBV) antibody category

From: Risk of classical Kaposi sarcoma by plasma levels of Epstein-Barr virus antibodies, sCD26, sCD23 and sCD30

EBV antibody tertile category Cases
N (%)
119
Seropositive controls
N (%)
105
ORadj* (95% CI) HRadj** (95% CI)
Low EBNA-1 43 (36%) 34 (32%) 0.97 (0.52 - 1.82) 0.93 (0.45 -1.98)
High VCA 42 (35%) 45 (43%) 0.87 (0.45 - 1.69) 1.10 (0.50 - 2.35)
Low EBNA-1/high VCA 5 (4%) 6 (6%) 0.55 (0.15 - 2.00) 0.53 (0.12 - 2.29)
EBNA-1/VCA category     
Low/High
Low/Not high
Not low/High
Not low/not high
5 (4%)
38 (32%)
37 (31%)
39 (33%)
6 (6%)
28 (27%)
39 (37%)
32 (30%)
0.56 (0.14 - 2.18)
1.08 (0.52 - 2.25)
0.98 (0.46 - 2.09)
Reference
0.62 (0.13 - 3.10)
1.20 (0.49 - 2.92)
1.23 (0.54 - 2.84)
Reference
EBV antibody tertile category Seropositive controls
N (%)
105
Seronegative controls
N (%)
155
ORadj† (95% CI) HRadj‡ (95% CI)
Low EBNA-1 34 (32%) 52 (34%) 0.98 (0.56 - 1.70) 1.04 (0.60 - 1.80)
High VCA 45 (43%) 42 (27%) 1.90 (1.04 - 3.47) 1.88 (1.04 - 3.40)
Low EBNA-1/high VCA 6 (6%) 6 (4%) 1.53 (0.47 -5.02) 1.00 (0.33 - 3.07)
EBNA-1/VCA category     
Low/High
Not low/High
Low/Not high
Not low/not high
6 (6%)
28 (27%)
39 (37%)
32 (30%)
6 (4%)
46 (30%)
36 (23%)
67 (42%)
2.11 (0.61 - 7.30)
1.18 (0.61 - 2.27)
2.02 (1.00 - 4.07)
Reference
1.76 (0.52 - 5.93)
1.43 (0.74 - 2.78)
2.20 (1.14 - 4.24)
Reference
  1. * Adjusted odds ratio (ORadj) comparing cases to KHSV seropositive controls with logistic regression (adjusted for age group, sex, smoking, diabetes, cortisone use)
  2. ** Adjusted hazard ratio (HRadj) comparing cases to seropositive controls using conditional logistic regression (adjusted for age group, sex, smoking, diabetes and cortisone, and conditioning on assay batch)
  3. † Adjusted odds ratio (ORadj) comparing all tested KSHV seropositive controls to seronegative controls with logistic regression models (adjusted for matching factors: age group, sex, smoking and diabetes).
  4. ‡ Adjusted hazard ratio (HRadj) comparing matched KSHV seropositive and seronegative controls using conditional logistic regression (conditioning on matched set and assay batch).