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Table 2 Distribution of Cytochrome P4501B1 alleles and genotypes in relation to breast cancer risk

From: Cytochrome P450 1B1 Val432Leu polymorphism and breast cancer risk in Nigerian women: a case control study

  Cases Controls OR (95% CI) OR (95% CI)*
All women (n = 228) (n = 226)   
Allele frequencies     
CYP1B1(Val) 0.86 0.89   
CYP1B1(Leu) 0.14 0.11   
Genotype frequencies     
CYP1B1 (Val/Val) 167 (47.85) 182 (52.15) 1.00  
CYP1B1 (Val/Leu) 57 (59.38) 39 (40.62) 1.59 (1.01–2.52) 1.57 (0.99–2.51)
CYP1B1 (Leu/Leu) 4 (44.44) 5 (55.6) 0.87 (0.23–3.30) 0.94 (0.24–3.64)
CYP1B1 (Val/Val) 167 (47.85) 182 (52.15) 1.00  
CYP1B1 (Val/Leu) + (Leu/Leu) 61 (58.10) 44 (41.90) 1.51 (0.92–2.35) 1.51 (0.96–2.36)
Pre-menopausal women (n = 125) (n = 129)   
Allele frequencies     
CYP1B1(Val) 0.85 0.92   
CYP1B1(Leu) 0.15 0.08   
Genotype frequencies     
CYP1B1 (Val/Val) 91 (45.50) 109 (54.50) 1.00  
CYP1B1 (Val/Leu) 30 (62.50) 18 (37.50) 2.00 (1.05–3.81) 1.97 (1.02–3.81)
CYP1B1 (Leu/Leu) 4 (66.67) 2 (33.33) 2.40 (0.43–13.38) 2.64 (0.46–15.23)
CYP1B1 (Val/Val) 91 (45.50) 109 (54.50) 1.00  
CYP1B1 (Val/Leu) + (Leu/Leu) 34 (62.96) 20 (37.04) 2.04 (1.10–3.78) 2.04 (1.07–3.81)
Postmenopausal women (n = 103) (n = 97)   
Allele frequencies     
CYP1B1(Val) 0.87 0.86   
CYP1B1(Leu) 0.13 0.14   
Genotype frequencies     
CYP1B1 (Val/Val) 76 (51.00) 73 (49.00) 1.00  
CYP1B1 (Val/Leu) 27 (56.30) 21 (43.80) 1.24 (0.64–2.38) 1.20 (0.62–2.34)
CYP1B1 (Leu/Leu) 0 (0.00) 3 (100.00) ** **
CYP1B1 (Val/Val) 76 (51.00) 73 (49.00) 1.00  
CYP1B1 (Val/Leu) + (Leu/Leu) 27 (52.94) 24 (47.06) 1.08 (0.57–2.04) 1.05 (0.55–2.01)
  1. * Adjusted for waist/hip ratio (WHR)
  2. ** Odds ratios could not be determined due to missing values in some cells