Table 2 Distribution of Cytochrome P4501B1 alleles and genotypes in relation to breast cancer risk

All women

(n = 228)

(n = 226)

Allele frequencies

CYP1B1(Val)

0.86

0.89

CYP1B1(Leu)

0.14

0.11

Genotype frequencies

CYP1B1 (Val/Val)

167 (47.85)

182 (52.15)

1.00

CYP1B1 (Val/Leu)

57 (59.38)

39 (40.62)

1.59 (1.01–2.52)

1.57 (0.99–2.51)

CYP1B1 (Leu/Leu)

4 (44.44)

5 (55.6)

0.87 (0.23–3.30)

0.94 (0.24–3.64)

CYP1B1 (Val/Val)

167 (47.85)

182 (52.15)

1.00

CYP1B1 (Val/Leu) + (Leu/Leu)

61 (58.10)

44 (41.90)

1.51 (0.92–2.35)

1.51 (0.96–2.36)

Pre-menopausal women

(n = 125)

(n = 129)

Allele frequencies

CYP1B1(Val)

0.85

0.92

CYP1B1(Leu)

0.15

0.08

Genotype frequencies

CYP1B1 (Val/Val)

91 (45.50)

109 (54.50)

1.00

CYP1B1 (Val/Leu)

30 (62.50)

18 (37.50)

2.00 (1.05–3.81)

1.97 (1.02–3.81)

CYP1B1 (Leu/Leu)

4 (66.67)

2 (33.33)

2.40 (0.43–13.38)

2.64 (0.46–15.23)

CYP1B1 (Val/Val)

91 (45.50)

109 (54.50)

1.00

CYP1B1 (Val/Leu) + (Leu/Leu)

34 (62.96)

20 (37.04)

2.04 (1.10–3.78)

2.04 (1.07–3.81)

Postmenopausal women

(n = 103)

(n = 97)

Allele frequencies

CYP1B1(Val)

0.87

0.86

CYP1B1(Leu)

0.13

0.14

Genotype frequencies

CYP1B1 (Val/Val)

76 (51.00)

73 (49.00)

1.00

CYP1B1 (Val/Leu)

27 (56.30)

21 (43.80)

1.24 (0.64–2.38)

1.20 (0.62–2.34)

CYP1B1 (Leu/Leu)

0 (0.00)

3 (100.00)

**

**

CYP1B1 (Val/Val)

76 (51.00)

73 (49.00)

1.00

CYP1B1 (Val/Leu) + (Leu/Leu)

27 (52.94)

24 (47.06)

1.08 (0.57–2.04)

1.05 (0.55–2.01)