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Table 2 Key clinical characteristics of the patients related to their serological response to HPV16 antigens

From: Clinical and epidemiological correlates of antibody response to human papillomaviruses (HPVs) as measured by a novel ELISA based on denatured recombinant HPV16 late (L) and early (E) antigens

Variables Anti-E and -L Anti-E4-E6 and E7 Anti L1 and -L2
  + - Sign. + - Sign. + - Sign.
HPV DNA (%):          
   Positive 76 89.5 10.5 OR = 2.8 (0.8–9.9) 71.1 28.9 OR = 1.3 (0.4–3.7) 71.1 28.9 OR = 1.6 (0.6–4.6)
    p = 0.136    p = 0.604    p = 0.350
   Negative 20 75.0 25.0   65.0 35.0   60.0 40.0  
HR-HPV (%)          
   Positive 66 87.9 12.1 OR = 1.4 (0.4–4.8) 68.2 31.8 OR = 0.8 (0.3–2.0) 69.7 30.3 OR = 1.1 (0.5–2.9)
    p = 0.536    p = 0.608    p = 0.767
   Negative 30 83.3 16.7   73.3 26.7   66.7 33.3  
LR-HPV (%):          
   Positive 10 100 0.0 OR = NC 90.0 10.0 OR = 4.3 (0.5–30.0) 80.0 20.0 OR = 1.9 (0.4–9.7):
    p = 0.348    p = 0.273    p = 0.720
   Negative 86 84.9 15.1   67.4 32.6   67.4 32.6  
Previous:          
HPV (%):          
   Yes 19 94.7 5.3 OR = 2.8 (0.3–23.9); 89.5 10.5 OR = 4.8 (1.1–22.8) 73.7 26.3 OR = 0.9 (0.3–3.1);
    p = 0.445    p = 0.046    p = 0.961
   No 66 86.4 13.6   63.6 36.4   74.2 25.8  
HIV-Status (%):          
   Negative 84 89.3 10.7 OR = 4.2(1.1–16.5) 71.4 28.6 OR = 1.8 (0.5–6.2) 72.6 27.4 OR = 3.7 (1.1–12.9)
    p = 0.032    p = 0.355    p = 0.030
   Positive 12 66.7 33.3   58.3 41.7   41.7 58.3  
   Smokers 9 66.6 33.3   55.6 44.4   33.3 66.7  
Previous:          
PAP (%):          
   Never 10 90.0 10.0 p = 0.793 70.0 30.0 p = 0.111 80.0 20.0 p = 0.445
   Irregular 26 92.3 7.7   84.6 15.4   61.5 38.5  
   Regular (1–3 yrs) 49 85.7 14.3   61.2 38.8   75.5 24.5  
Referral          
PAP (%):          
   ASC-US 7 100 0.0 p = 0.431 85.7 14.3 p = 0.623 100 0.0 p = 0.094
   LSIL 48 91.7 8.3   64.6 35.4   75.0 25.0 p = 0.031*
   HSIL 16 81.3 18.7   68.8 31.2   56.3 43.7  
Biopsy          
Result (%):          
   Normal 1 100 0.0   0.0 100   100 0.0  
   HPV-NCIN 9 100 0.0 p = 0.262 66.7 33.3 p = 0.526 77.8 22.2 p = 0.564
   CIN1 11 90.9 9.1   54.5 45.5   63.6 36.4  
   CIN2 14 92.9 7.1   71.4 28.6   85.7 14.3  
   CIN3 15 93.3 6.7   73.3 16.7   73.3 26.7  
   SCC 2 50.0 50.0   50.0 50.0   50.0 50.0  
Genital          
Warts (%):          
   Yes 20 95.0 5.0 OR = 3.3(0.4–27.7) 80.0 20.0 OR = 2.1 (0.6–7.0) 75.0 25.0 OR = 1.1 (0.4–3.7)
    p = 0.437    p = 0.275    p = 0.801
   No 61 85.2 14.8   65.6 34.4   72.1 27.9  
Colposcopy (%):          
   Normal 2 100 0.0   100 0.0   0.0 100  
   Low-grade 27 96.3 3.74 p = 0.177 63.0 37.0 p = 0.668 85.2 14.8 p = 0.015
   High-grade 28 77.8 22.2   72.2 27.8   61.1 28.9  
  1. NC, non-computable; 1Contraception used until past; 2Contraception in current use; *For linear trend; HPV-NCIN, HPV infection without CIN....