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Table 2 Key clinical characteristics of the patients related to their serological response to HPV16 antigens

From: Clinical and epidemiological correlates of antibody response to human papillomaviruses (HPVs) as measured by a novel ELISA based on denatured recombinant HPV16 late (L) and early (E) antigens

Variables

Anti-E and -L

Anti-E4-E6 and E7

Anti L1 and -L2

 

+

-

Sign.

+

-

Sign.

+

-

Sign.

HPV DNA (%):

         

   Positive 76

89.5

10.5

OR = 2.8 (0.8–9.9)

71.1

28.9

OR = 1.3 (0.4–3.7)

71.1

28.9

OR = 1.6 (0.6–4.6)

   

p = 0.136

  

p = 0.604

  

p = 0.350

   Negative 20

75.0

25.0

 

65.0

35.0

 

60.0

40.0

 

HR-HPV (%)

         

   Positive 66

87.9

12.1

OR = 1.4 (0.4–4.8)

68.2

31.8

OR = 0.8 (0.3–2.0)

69.7

30.3

OR = 1.1 (0.5–2.9)

   

p = 0.536

  

p = 0.608

  

p = 0.767

   Negative 30

83.3

16.7

 

73.3

26.7

 

66.7

33.3

 

LR-HPV (%):

         

   Positive 10

100

0.0

OR = NC

90.0

10.0

OR = 4.3 (0.5–30.0)

80.0

20.0

OR = 1.9 (0.4–9.7):

   

p = 0.348

  

p = 0.273

  

p = 0.720

   Negative 86

84.9

15.1

 

67.4

32.6

 

67.4

32.6

 

Previous:

         

HPV (%):

         

   Yes 19

94.7

5.3

OR = 2.8 (0.3–23.9);

89.5

10.5

OR = 4.8 (1.1–22.8)

73.7

26.3

OR = 0.9 (0.3–3.1);

   

p = 0.445

  

p = 0.046

  

p = 0.961

   No 66

86.4

13.6

 

63.6

36.4

 

74.2

25.8

 

HIV-Status (%):

         

   Negative 84

89.3

10.7

OR = 4.2(1.1–16.5)

71.4

28.6

OR = 1.8 (0.5–6.2)

72.6

27.4

OR = 3.7 (1.1–12.9)

   

p = 0.032

  

p = 0.355

  

p = 0.030

   Positive 12

66.7

33.3

 

58.3

41.7

 

41.7

58.3

 

   Smokers 9

66.6

33.3

 

55.6

44.4

 

33.3

66.7

 

Previous:

         

PAP (%):

         

   Never 10

90.0

10.0

p = 0.793

70.0

30.0

p = 0.111

80.0

20.0

p = 0.445

   Irregular 26

92.3

7.7

 

84.6

15.4

 

61.5

38.5

 

   Regular (1–3 yrs) 49

85.7

14.3

 

61.2

38.8

 

75.5

24.5

 

Referral

         

PAP (%):

         

   ASC-US 7

100

0.0

p = 0.431

85.7

14.3

p = 0.623

100

0.0

p = 0.094

   LSIL 48

91.7

8.3

 

64.6

35.4

 

75.0

25.0

p = 0.031*

   HSIL 16

81.3

18.7

 

68.8

31.2

 

56.3

43.7

 

Biopsy

         

Result (%):

         

   Normal 1

100

0.0

 

0.0

100

 

100

0.0

 

   HPV-NCIN 9

100

0.0

p = 0.262

66.7

33.3

p = 0.526

77.8

22.2

p = 0.564

   CIN1 11

90.9

9.1

 

54.5

45.5

 

63.6

36.4

 

   CIN2 14

92.9

7.1

 

71.4

28.6

 

85.7

14.3

 

   CIN3 15

93.3

6.7

 

73.3

16.7

 

73.3

26.7

 

   SCC 2

50.0

50.0

 

50.0

50.0

 

50.0

50.0

 

Genital

         

Warts (%):

         

   Yes 20

95.0

5.0

OR = 3.3(0.4–27.7)

80.0

20.0

OR = 2.1 (0.6–7.0)

75.0

25.0

OR = 1.1 (0.4–3.7)

   

p = 0.437

  

p = 0.275

  

p = 0.801

   No 61

85.2

14.8

 

65.6

34.4

 

72.1

27.9

 

Colposcopy (%):

         

   Normal 2

100

0.0

 

100

0.0

 

0.0

100

 

   Low-grade 27

96.3

3.74

p = 0.177

63.0

37.0

p = 0.668

85.2

14.8

p = 0.015

   High-grade 28

77.8

22.2

 

72.2

27.8

 

61.1

28.9

 
  1. NC, non-computable; 1Contraception used until past; 2Contraception in current use; *For linear trend; HPV-NCIN, HPV infection without CIN....