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Table 1 Key epidemiological data of patients related to their serological response to HPV16 antigens

From: Clinical and epidemiological correlates of antibody response to human papillomaviruses (HPVs) as measured by a novel ELISA based on denatured recombinant HPV16 late (L) and early (E) antigens

Variables Anti-E and -L Anti-E4-E6 and E7 Anti L1 and -L2
  + - Sign. + - Sign. + - Sign.
Mean Age (yrs) 34.9 36.9 p = 0.460 34.8 36.0 p = 0.533 36.1 35.6 p = 0.805
Smoking status %         
Non-smoker (40) 92.5 7.5 OR = 2.8 (0.7–11.3); 72.5 17.5 OR = 1.4 (0.6–3.6); 85.0 15.0 OR = 3.7 (1.3–10.5);
    p = 0.211    p = 0.495    p = 0.009
Current smoker (48) 81.3 18.7   64.6 35.4   60.4 39.6  
N. cigarette/d 13.4 10.1 p = 0.285 13.8 10.9 p = 0.225 13.3 12.0 p = 0.603
Age start smoking (yrs) 18.9 19.6 p = 0.776 18.2 20.6 p = 0.122 19.5 18.1 p = 0.379
Years smoked 15.2 13.3 p = 0.592 16.5 12.0 p = 0.089 14.0 16.8 p = 0.296
1 Contraception (%):          
   Yes (53) 92.5 7.5 OR = 1.4 (0.3–6.8); 73.6 26.4 OR = 1.3 (0.5–3.4): 73.6 26.4 OR = 0.7 (0.2–2.1):
    p = 0.694    p = 0.658    p = 0.560
   No (29) 89.7 10.3   69.0 31.0   79.3 20.7  
^New partner (%):          
   Yes (5) 100 - OR = NC; p = 0.508 60.0 40.0 OR = 0.7 (0.2–2.2); 60.0 40.0 OR = 0.7 (0.2–2.1);
       p = 0.630    p = 0.619
   No (76) 86.8 13.2   71.1 28.9   72.4 27.6  
Sexually active (%):          
   Yes (79) 89.9 10.1 OR = 5.9 (0.9–40.9); 70.9 29.1 OR = 1.6 (0.3–10.4); 74.7 25.3 OR = 4.4 (0.7–28.4);
    p = 0.105    p = 0.631    p = 0.124
   No (5) 60.0 40.0   60.0 40.0   40.0 60.0  
Partner HIV+ (%):          
   Yes (8) 87.5 12.5 OR = 0.9 (0.1–8.7); 87.5 12.5 OR = 3.3 (0.4–28.3); 62.5 37.5 OR = 0.6 (0.1–2.8);
    p = 1.000       p = 0.679
   No (75) 88.0 12.0   68.0 32.0   73.3 26.7  
2 Actual contraception %         
   Yes (37) 86.5 13.5 OR = 0.7 (0.2–2.7); 67.6 32.4 OR = 0.8 (0.3–2.1); 64.9 35.1 OR = 0.4 (0.1–1.1);
    p = 0.726    p = 0.660    p = 0.093
   No (43) 90.7 9.3   72.1 27.9   81.4 18.6  
2 Condom Use %         
   Never (43) 90.7 9.3   72.1 27.9   72.1 27.9  
   Often (14) 100 - p = 0.138 78.6 21.4 p = 0.334 100 - p = 0.022
   Always (18) 77.8 22.2   55.6 44.4   61.1 38.9  
STD since last visit %         
   Yes (6) 100 - OR = NC; 100 - OR = NC; 83.3 16.7 OR = 1.7 (0.2–15.7)
    p = 1.000    p = 0.175    
   No (74) 89.2 10.8   68.9 31.1   74.3 25.7  
  1. NC, non-computable; 1Contraception used until past; 2Contraception in current use; *For linear trend; HPV-NCIN, HPV infection without CIN.... ^New partner since last visit