Table 6 Summary of case-control studies investigating various HPV types in the aetiology of ocular surface squamous neoplasias
Study | Detection method | Number HPV positive/total (%) | HPV type | |
|---|---|---|---|---|
| Â | Â | Case | Control | Â |
McDonnell et al, 1986 [58] | In situ HPV antigen detection | 5/61 (8%) | 0/6 (0%) | Unknown genital HPV type |
McDonnell et al, 1989 [59] | PCR | 6/6 (100%) | 0/6 (0%) | HPV 16 |
Saegusa et al, 1995 [60] | ISH and PCR | 3/8 (38%) | 0/12 (0%) | HPV 16 |
Adachi et al, 1995 [61] | PCR | 1/5 (20%) | 0/9 (0%) | HPV 16 |
Waddell et al, 1996 [30] | PCR | 7/20 (35%) | 2/15 (13%) | HPV 16 |
Karcioglu and Issa, 1997 [62] | PCR | 4/45 (9%) | 8/70 (11%) | HPV 16 |
| Â | Â | 10/45 (22%) | 10/70 (14%) | HPV 18 |
Tabrizi et al, 1997 [63] | PCR | 20/88 (23%) | 5/66 (8%) | HPV 16 or 18 |
Dushku et al, 1999 [64] | PCR | 0/8 (0%) | 0/16 (0%) | L1 (all types) |
Palazzi et al, 2000 [65] | PCR | 2/30 (7%) | 1/30 (3%) | HPV 16 |
Scott et al, 2002 [66] | ISH and in situ reverse transcriptase PCR | Â | Â | Â |
| Â | Â | 5/10 (50%) | 0/5 (0%) | HPV 16 |
| Â | Â | 5/10 (50%) | 0/5 (0%) | HPV 18 |
Newton et al, 2002 [11] | Serological analysis | 8/39 (21%) | 43/418 (10%) | HPV 16 |
| Â | Â | 4/39 (10%) | 16/418 (4%) | HPV 18 |
| Â | Â | 2/39 (5%) | 24/418 (6%) | HPV 45 |
Tulvatana et al, 2003 [7] | PCR | 0/28 (0%) | 0/23 (0%) | Multiple types |
Waddell et al, 2003 [67] | Serological analysis | 37/253 (15%) | 6/37 (16) | HPV 16 |
Ateenyi-Agaba et al, 2004 [68] | PCR | 0/21 (0%) | 0/22 (0%) | HPV 16, 18 and 45 |
| Â | Â | 0/22 (0%) | 2/22 (9%) | HPV 11 |
| Â | Â | 18/21 (86%) | 7/20 (35%) | Multiple cutaneous HPV types |
Tornesello et al, 2006 [69] | PCR | 0/86 (0%) | 1/63 (2%) | HPV 6 |
| Â | Â | 2/86 (2%) | 0/63 (0%) | HPV 18 |
| Â | Â | 15/86 (17%) | 0/63 (0%) | Multiple cutaneous HPV types |
Sen et al, 2007 [70] | In situ HPV antigen detection | 0/30 (0%) | 0/30 (0%) | Multiple genital HPV types |
de Koning et al [this study] | PCR | 31/81 (38%) | 11/29 (38%) | Multiple genital HPV types |
| Â | Â | 18/81 (22%) | 1/29 (3%) | Multiple cutaneous HPV types1 |