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Table 6 Summary of case-control studies investigating various HPV types in the aetiology of ocular surface squamous neoplasias

From: Genital and cutaneous human papillomavirus (HPV) types in relation to conjunctival squamous cell neoplasia: A case-control study in Uganda

Study Detection method Number HPV positive/total (%) HPV type
   Case Control  
McDonnell et al, 1986 [58] In situ HPV antigen detection 5/61 (8%) 0/6 (0%) Unknown genital HPV type
McDonnell et al, 1989 [59] PCR 6/6 (100%) 0/6 (0%) HPV 16
Saegusa et al, 1995 [60] ISH and PCR 3/8 (38%) 0/12 (0%) HPV 16
Adachi et al, 1995 [61] PCR 1/5 (20%) 0/9 (0%) HPV 16
Waddell et al, 1996 [30] PCR 7/20 (35%) 2/15 (13%) HPV 16
Karcioglu and Issa, 1997 [62] PCR 4/45 (9%) 8/70 (11%) HPV 16
   10/45 (22%) 10/70 (14%) HPV 18
Tabrizi et al, 1997 [63] PCR 20/88 (23%) 5/66 (8%) HPV 16 or 18
Dushku et al, 1999 [64] PCR 0/8 (0%) 0/16 (0%) L1 (all types)
Palazzi et al, 2000 [65] PCR 2/30 (7%) 1/30 (3%) HPV 16
Scott et al, 2002 [66] ISH and in situ reverse transcriptase PCR    
   5/10 (50%) 0/5 (0%) HPV 16
   5/10 (50%) 0/5 (0%) HPV 18
Newton et al, 2002 [11] Serological analysis 8/39 (21%) 43/418 (10%) HPV 16
   4/39 (10%) 16/418 (4%) HPV 18
   2/39 (5%) 24/418 (6%) HPV 45
Tulvatana et al, 2003 [7] PCR 0/28 (0%) 0/23 (0%) Multiple types
Waddell et al, 2003 [67] Serological analysis 37/253 (15%) 6/37 (16) HPV 16
Ateenyi-Agaba et al, 2004 [68] PCR 0/21 (0%) 0/22 (0%) HPV 16, 18 and 45
   0/22 (0%) 2/22 (9%) HPV 11
   18/21 (86%) 7/20 (35%) Multiple cutaneous HPV types
Tornesello et al, 2006 [69] PCR 0/86 (0%) 1/63 (2%) HPV 6
   2/86 (2%) 0/63 (0%) HPV 18
   15/86 (17%) 0/63 (0%) Multiple cutaneous HPV types
Sen et al, 2007 [70] In situ HPV antigen detection 0/30 (0%) 0/30 (0%) Multiple genital HPV types
de Koning et al [this study] PCR 31/81 (38%) 11/29 (38%) Multiple genital HPV types
   18/81 (22%) 1/29 (3%) Multiple cutaneous HPV types1