TY - JOUR AU - Feller, Liviu AU - Lemmer, Johan PY - 2008 DA - 2008/01/21 TI - Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma JO - Infectious Agents and Cancer SP - 1 VL - 3 IS - 1 AB - A decrease in the incidence of human immune deficiency virus-associated Kaposi sarcoma (HIV-KS) and regression of some established HIV-KS lesions is evident after the introduction of highly active anti-retroviral treatment (HAART), and is attributed to generalized immune restoration, to the reconstitution of human herpesvirus (HHV)-8 specific cellular immune responses, and to the decrease in HIV Tat protein and HHV-8 loads following HAART. However, a small subset of HIV-seropositive subjects with a low CD4+ T cell count at the time of introduction of HAART, may develop HIV-KS as immune reconstitution inflammatory syndrome (IRIS) within 8 weeks thereafter. SN - 1750-9378 UR - https://doi.org/10.1186/1750-9378-3-1 DO - 10.1186/1750-9378-3-1 ID - Feller2008 ER -