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Table 1 Experimental infection of Dexamethasone-treated or untreated SCID mice infected with C. parvum or C. muris: Main clinical and histopathological data

From: Cryptosporidium parvum, a potential cause of colic adenocarcinoma

Groupa Mouse N° Day of euthanasia (post-infection) Oocysts/mg faeces at euthanasia Clinical manifestations Main histological changes
P 1 20 0 Occasional diarrhoea Undetected
  2 28 0 Lethargy Undetected
  3 28 1 None N.D.
  4 84 1 Occasional diarrhoea Undetected
  5 84 4 Occasional diarrhoea Undetected
  6 84 0 Occasional diarrhoea N.D.
Pdex 7 20 29 Occasional diarrhoea Undetected
  8 28 102 Lethargy, ruffled coat Undetected
  9 28 95 Lethargy, ruffled coat N.D.
  10 46 1182 Lethargy, ruffled coat Polyps with areas of low-grade and high-grade intraepithelial neoplasia, and intramucosal adenocarcinoma at the ileocaecal region
  11 62 240 Lethargy, ruffled coat Polyps with areas of low-grade and high-grade intraepithelial neoplasia, and intramucosal adenocarcinoma at the ileocaecal region
  12 84 695 Lethargy, ruffled coat Polyps with areas of low-grade and high-grade intraepithelial neoplasia, and intramucosal adenocarcinoma at the ileocaecal region
M 13 20 1078 None Stomach heavily infected mainly at the fundic region; dilated glands; hyperplasia
  14 20 407 None N.D.
  15 28 742 None Stomach heavily infected mainly at the fundic glands, hyperplasia
  16 84 4143 None Stomach heavily infected mainly at the fundic region; dilated glands; hyperplasia
  17 84 4920 None Stomach heavily infected
  18 84 5828 None None
Mdex 19 20 1538 Occasional diarrhoea Stomach heavily infected; dilated glands
  20 20 166 Occasional diarrhoea N.D.
  21 27 1241 Occasional diarrhoea N.D.
  22 32 4155 Frequent diarrhoea, lethargy, ruffled coat Stomach heavily infected mainly at the fundic glands; hyperplasia
  23 46 900 Lethargy, ruffled coat Stomach heavily infected mainly at the fundic glands; hyperplasia
  24 84 2051 None Stomach heavily infected mainly at the fundic glands; hyperplasia; a little inflammation
C 25 20 0 None Undetected
  26 67 0 Lethargy, ruffled coat Undetected
  27 84 0 None Undetected
Cdex 28 20 0 None Undetected
  29 43 0 None Undetected
  30 84 0 None Undetected
Cdex2 31 54 0 None Undetected
  32 54 0 None Undetected
  33 54 0 None Undetected
  34 54 0 None Undetected
  35 54 0 None Undetected
  36 54 0 None Undetected
  1. aExperimental groups were:
  2. P: C. parvum-infected SCID mice; PDex: C. parvum-infected Dex-treated SCID mice; M: C. muris-infected SCID mice; MDex: C. muris-infected Dex-treated SCID mice; C: Not infected SCID mice of control group inoculated with PBS; CDex: Not infected Dex-treated SCID mice of control group inoculated with PBS; CDex2: Not infected Dex-treated SCID mice that received an inoculum from which oocysts were previously removed by filtration; N.D.: Not done (These mice were not included in the histological examination).