Cryptosporidium parvum, a potential cause of colic adenocarcinoma

Certad, Gabriela; Ngouanesavanh, Tramy; Guyot, Karine; Gantois, Nausicaa; Chassat, Thierry; Mouray, Anthony; Fleurisse, Laurence; Pinon, Anthony; Cailliez, Jean-Charles; Dei-Cas, Eduardo; Creusy, Colette

doi:10.1186/1750-9378-2-22

Infectious Agents and Cancer

Table 1 Experimental infection of Dexamethasone-treated or untreated SCID mice infected with C. parvum or C. muris: Main clinical and histopathological data

From: Cryptosporidium parvum, a potential cause of colic adenocarcinoma

Group^a	Mouse N°	Day of euthanasia (post-infection)	Oocysts/mg faeces at euthanasia	Clinical manifestations	Main histological changes
P	1	20	0	Occasional diarrhoea	Undetected
	2	28	0	Lethargy	Undetected
	3	28	1	None	N.D.
	4	84	1	Occasional diarrhoea	Undetected
	5	84	4	Occasional diarrhoea	Undetected
	6	84	0	Occasional diarrhoea	N.D.
Pdex	7	20	29	Occasional diarrhoea	Undetected
	8	28	102	Lethargy, ruffled coat	Undetected
	9	28	95	Lethargy, ruffled coat	N.D.
	10	46	1182	Lethargy, ruffled coat	Polyps with areas of low-grade and high-grade intraepithelial neoplasia, and intramucosal adenocarcinoma at the ileocaecal region
	11	62	240	Lethargy, ruffled coat	Polyps with areas of low-grade and high-grade intraepithelial neoplasia, and intramucosal adenocarcinoma at the ileocaecal region
	12	84	695	Lethargy, ruffled coat	Polyps with areas of low-grade and high-grade intraepithelial neoplasia, and intramucosal adenocarcinoma at the ileocaecal region
M	13	20	1078	None	Stomach heavily infected mainly at the fundic region; dilated glands; hyperplasia
	14	20	407	None	N.D.
	15	28	742	None	Stomach heavily infected mainly at the fundic glands, hyperplasia
	16	84	4143	None	Stomach heavily infected mainly at the fundic region; dilated glands; hyperplasia
	17	84	4920	None	Stomach heavily infected
	18	84	5828	None	None
Mdex	19	20	1538	Occasional diarrhoea	Stomach heavily infected; dilated glands
	20	20	166	Occasional diarrhoea	N.D.
	21	27	1241	Occasional diarrhoea	N.D.
	22	32	4155	Frequent diarrhoea, lethargy, ruffled coat	Stomach heavily infected mainly at the fundic glands; hyperplasia
	23	46	900	Lethargy, ruffled coat	Stomach heavily infected mainly at the fundic glands; hyperplasia
	24	84	2051	None	Stomach heavily infected mainly at the fundic glands; hyperplasia; a little inflammation
C	25	20	0	None	Undetected
	26	67	0	Lethargy, ruffled coat	Undetected
	27	84	0	None	Undetected
Cdex	28	20	0	None	Undetected
	29	43	0	None	Undetected
	30	84	0	None	Undetected
Cdex2	31	54	0	None	Undetected
	32	54	0	None	Undetected
	33	54	0	None	Undetected
	34	54	0	None	Undetected
	35	54	0	None	Undetected
	36	54	0	None	Undetected

^aExperimental groups were:
P: C. parvum-infected SCID mice; PDex: C. parvum-infected Dex-treated SCID mice; M: C. muris-infected SCID mice; MDex: C. muris-infected Dex-treated SCID mice; C: Not infected SCID mice of control group inoculated with PBS; CDex: Not infected Dex-treated SCID mice of control group inoculated with PBS; CDex2: Not infected Dex-treated SCID mice that received an inoculum from which oocysts were previously removed by filtration; N.D.: Not done (These mice were not included in the histological examination).

Back to article page

ISSN: 1750-9378

Contact us

General enquiries: journalsubmissions@springernature.com