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Table 5 Percent of CIN cases estimated to be attributable to nine specific HPV types & any HPV type in prior US studies

From: Progression and regression of incident cervical HPV 6, 11, 16 and 18 infections in young women

     % of Cases Estimated to be Attributable to Specific HPV types  
Year Author N Testing Method HPV 6 HPV 11 HPV 16 HPV 18 HPV 31 HPV 33 HPV 45 HPV 52 HPV 58 Any HPV type*
CIN 1 30,31,39–41,43              
2006 Srodon, M 36 PCR/Biopsy 2.8 2.8 11.1 16.7 5.6 5.6 5.6 2.8 2.8 100.0
2005 Hu, L 45 PCR/Biopsy    6.4 2.2 3.1 0.0 2.2 12.2 7.2 87.0
2002 Evans, M 28 PCR/Biopsy 4.5 3.6 7.1 3.6 7.1 3.6 3.6 7.1 0.0 100.0
1998 Aoyama, C 11 PCR/Biopsy 0.0 0.0 27.3 9.1 9.1 9.1     54.5
1998 Quade, B 30 PCR/Biopsy 3.3 3.3 10.0 3.3 6.7 0.0 0.0 0.0 0.0 73.3
1996 Isacson, C 40 PCR/Biopsy 5.0 10.0         
Total   190   3.6 4.8 9.9 6.7 5.6 2.7 2.9 6.1 3.0 87.4
CIN 2/3 30,31,39–43              
2006 Srodon, M 116 PCR/Biopsy 0.0 0.0 75.0 4.3 5.2 1.7 0.0 0.9 3.4 100.0
2005 Hu, L 97 PCR/Biopsy    38.9 9.6 11.6 1.0 1.1 5.0 2.6 93.6
2002 Evans, M 22 PCR/Biopsy 0.0 0.0 68.2 4.5 9.1 4.5 4.5 0.0 4.5 100.0
1998 Aoyama, C 21 PCR/Biopsy 0.0 0.0 52.4 0.0 19.0 19.0     95.2
1998 Quade, B 19 PCR/Biopsy 0.0 0.0 52.6 5.3 0.0 15.8 0.0 0.0 0.0 78.9
1996 Isacson, C 11 PCR/Biopsy 0.0 0.0 45.5 0.0 18.2 9.1 0.0 0.0 0.0 100.0
1993 Shroyer, K 13 PCR/Biopsy 0.0 0.0 61.5 0.0       92.3
Total   299   0.0 0.0 58.1 5.5 8.8 4.2 0.8 2.2 2.8 95.9
  1. * As determined by consensus PCR primers sensitive to positivity for at least 10 HPV types.
  2. Lesions in these studies containing multiple HPV types were fractionally attributed to individual HPV types as described in the Methods section. Without this method of attribution, original figures for HPV prevalence differing from those reported in the table were as follows: Evans et al., CIN 1 (HPV 6 – 7.1%); Hu et al., CIN 1 (HPV 16 – 8.9%, 31 – 6.7%, 52 – 13.3%, 58 – 11.1%), CIN 2/3 (HPV 16 – 40.2%, 18 – 12.4%, 31 – 13.4%, 45 – 2.1%, 52 – 8.2%, 58 – 6.2%)
  3. CIN = cervical intraepithelial neoplasia; HPV = human papillomavirus; PCR = polymerase chain reaction