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Table 1 Individual microscopic findings

From: Immunization of mice with the nef gene from Human Immunodeficiency Virus type 1: Study of immunological memory and long-term toxicology

Group:Animal

Lung

Liver

Spleen

Lymph Node

Kidney

Ovaries

MVAx3:1

0

0

0

0

0

nd

MVAx3:2

Congestion 3

0

0

nd

0

0

MVAx3:3

0

0

0

nd

0

nd

MVAx3:4

0

0

0

0

0

0

MVAx3:5

0

MiFo inflammation 2

0

0

Unilateral Chro pyelonephritis 1

0

MVAx3:6

Lymphoid cell acc. 2

MiFo inflammation 1

0

0

0

0

MVAx3:7

Lymphoid cell acc. 2

0

0

0

0

0

MVAx3:8

0

Peri. inflammation 2

Incr. extramedullary hematopoiesis 2

nd

0

0

MVAx3:9

0

0

0

nd

0

Unilateral cyst

MVAx3:10

Lymphoid cell acc. 1

Peri. inflammation 1

Incr. extramedullary hematopoiesis 1 Hemosiderosis 1

0

0

nd

PBSx2+MVAx1:1

Lymphoid cell acc. 1

MiFo inflammation 1

0

nd

0

0

PBSx2+MVAx1:2

0

0

0

nd

0

nd

PBSx2+MVAx1:3

0

0

0

nd

0

0

PBSx2+MVAx1:4

0

0

0

0

0

0

PBSx3:1

0

MiFo inflammation 2

Lymphoid hyperplasia 1

0

0

0

PBSx3:2

Lymphoid cell acc. 1

0

0

nd

0

0

PBSx3:3

0

0

0

nd

0

0

PBSx3:4

0

0

0

nd

0

nd

PBSx3:5

0

0

0

0

0

0

PBSx3:6

0

0

0

0

0

0

  1. Abbreviations: acc = accumulation, MiFo = Microfocal, Incr = Increased, Peri = Periportal, Chro = Chronic, nd = not done
  2. Grading of changes: 0 = No changes, 1 = Minimal changes, 2 = Slight changes, 3 = moderate changes, 4 = Marked changes, 5 = Severe changes,