Table 1 Cytological and histological criteria used for diagnosis of cervical lesions
Lesions | Criteria for diagnosis | Ref. |
|---|---|---|
Cytologic HPV | Koilocytic atypia Multinucleation (frequently binucleation) Dyskeratosis Parakeratosis | 34 |
ASCUS | Nuclear enlargement approximately twice the size of an immature squamous metaplastic cell Slight increase in nucleo-cytoplasmic ratio Nuclear chromatin clumping Variation in nuclear size and shape including mild hyperchromasia, binucleation, and mild irregularity in the nuclear membranes | 35, 36 |
AGCUS | Nuclear enlargement approximately twice the size of an endocervical cell. Nuclear pseudostratification Mild hyperchromasia | 37 |
Discriminating AGUS from neoplastic endocervical cells | Presence of normal ECCs, singly or in sheets Absence of necrosis Absence of papillary groups Mild anisonucleosis Marked chromatin distribution | 37 |
EGD | Nuclei not cytologically malignant Nuclear hyperchromasia and pseudostratification Low mitotic figures Absence of papillary formation and cribriform pattern | 38 |
Histologic HPV | Koilocytic atypia: 4 points Binucleation: 2 points Dyskeratosis: one point Basal cell hyperplasia: one point Papillomatosis: one point Acanthosis: one point | 34 |