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Table 1 Demographic and clinical characteristics of the study participants by site

From: HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts

 

INI

VCCC

Pvaluea

N = 2,925

N = 3,927

Female sex (%)

978 (33)

938 (24)

<0.01

HIV transmission risk categoriesb (%)

  

<0.01

MSM

1,035 (35)

1,569 (40)

 

IDU

41 (1)

374 (10)

Heterosexual males

714 (24)

456 (12)

Heterosexual females

969 (33)

835 (21)

All others

166 (6)

693 (18)

Median age in years at clinic entry [IQR]

36 [29–43]

38 [31–45]

<0.01

Race (%)

  

0.69

White

1,552 (53)

2,103 (54)

Non-white

1,373 (47)

1,824 (46)

Median CD4+ lymphocyte count at clinic entry (cells/ÎĽL) [IQR]

287 [106–504]

325 [153–518]

<0.01

Missing CD4+ lymphocyte count at clinic entry (%)

884 (30)

346 (9)

<0.01

Median log10 HIV-1 RNA level at clinic entry (copies/mL) [IQR]

4.5 [3.6-5.2]

4.3 [3.1-5.0]

<0.01

Missing HIV-1 RNA at clinic entry (%)

1,364 (47)

322 (8)

<0.01

Median year of clinic entry [IQR]

2006 [2003–2008]

2004 [2001–2007]

<0.01

Hepatitis C virus infectionc (%)

243 (9)

537 (14)

<0.01

Missing hepatitis C virus infection data (%)

216 (7)

0

<0.01

Hepatitis B virus infectionc (%)

160 (6)

216 (6)

0.13

Missing hepatitis B virus infection data (%)

433 (15)

0

<0.01

History of tobacco used (%)

1,131/2,129 (53)

1,319/2,155 (61)

<0.01

Missing tobacco history (%)

796 (27)

1,772 (45)

<0.01

History of cancer prior to clinic entry (%)

56 (2)

105 (3)

0.04

History of ART exposure prior to clinic entry (%)

759 (26)

1,566 (40)

<0.01

Median follow-up time in years [IQR]

3.5 [1.5-6.1]

3.1 (1.1-6.5)

<0.01

Receipt of any ART during follow-up (%)

2,158 (74)

3,145 (80)

<0.01

  1. aP value result refers to results of Chi square test (categorical and binary variables) or Wilcoxon rank sum test (continuous variables).
  2. bHIV transmission risk categories are mutually exclusive.
  3. cHepatitis C and hepatitis B infection status at clinic entry for VCCC and at any point obtained during follow-up at INI, as many patients there did not have serologic testing until after clinic entry.
  4. dTobacco use was available from single, cross-sectional surveys completed by some patients at both clinic sites that was performed without relation to this study.
  5. Abbreviations:
  6. INI: Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
  7. VCCC: Vanderbilt Comprehensive Care Clinic, Nashville, TN, USA.
  8. MSM: men who have sex with men.
  9. IDU: injection drug use.
  10. ART: antiretroviral therapy.