Infectious Agents and Cancer

Table 1 Results of real-time quantitative PCR to detect various viruses in the 39 patients with GBM and in positive control samples

From: Prevalence of human cytomegalovirus, polyomaviruses, and oncogenic viruses in glioblastoma among Japanese subjects

			Viral DNA copy number*
Case no.	Age	Sex	HCMV			MCPyV	HPyV6	HPyV7	HPyV9	EBV	HHV8	HPV			Cell number
Case no.	Age	Sex	gB	IE	PCR**	MCPyV	HPyV6	HPyV7	HPyV9	EBV	HHV8	Type 16	Type 18	PCR***	Cell number
1	60	F	0	0	ND	0	0	0	0	0	0	0	0	ND	32
2	58	F	0	0	ND	0	0	0	0	0	0	0	0	ND	676
3	51	M	0	0	ND	0	0	0	0	0	0	0	0	type 16	417
4	74	F	0	0	ND	0	0	0	0	0	0	0	0	ND	1280
5	72	M	0	0	ND	0	0	0	0	0	0	0.13	0	type 16	21
6	68	F	0	0	ND	0	0	0	0	0	0	0	0	ND	135
7	49	M	0	0	ND	0	0	0	0	0	0	0	0	ND	770
8	71	M	0	0	ND	0	0	0	0	0	0	0	0	type 16	118
9	60	M	0	0	ND	0	0	0	0	0	0	0	0	ND	370
10	42	M	0	0	ND	0	0	0	0	0	0	0	0	ND	34
11	42	M	0	0	ND	0	0	0	0	0	0	0	0	ND	221
12	82	F	0	0	ND	0	0	0	0	0	0	0	0	ND	1236
13	40	M	0	0	ND	0	0	0	0	0	0	0	0	ND	48
14	77	M	0	0	ND	0	0	0	0	0	0	0	0	ND	301
15	62	F	0	0	ND	0	0	0	0	0	0	0	0	ND	454
16	75	M	0	0	ND	0	0	0	0	0	0	0	0	ND	138
17	73	M	0	0	ND	0	0	0	0	0	0	0	0	ND	26
18	43	F	0	0	ND	0	0	0	0	0	0	0	0	ND	157
19	50	F	0	0	ND	0	0	0	0	0	0	0	0	ND	133
20	46	M	0	0	ND	0	0	0	0	0	0	0	0	ND	5
21	82	M	0	0	ND	0	0	0	0	0	0	0	0	ND	114
22	4	F	0	0	ND	0	0	0	0	0	0	0	0	ND	954
23	46	M	0	0	ND	0	0	0	0	0	0	0	0	ND	533
24	70	F	0	0	ND	0	0	0	0	0	0	0	0	ND	590
25	65	F	0	0	ND	0	0	0	0	0	0	0	0	ND	33
26	59	F	0	0	ND	0	0	0	0	0	0	0	0	type 16	400
27	72	M	0	0	ND	0	0	0	0	0	0	0	0	ND	147
28	77	M	0	0	ND	0	0	0	0	0	0	0	0	ND	272
29	65	F	0	0	ND	0	0	0	0	0	0	0	0.05	type 18	50
30	72	M	0	0	ND	0	0	0	0	0	0	0	0	ND	214
31	77	M	0	0	ND	0	0	0	0	0	0	0	0	type 16	388
32	51	F	0	0	ND	0	0	0	0	0	0	0	0	ND	2637
33	77	F	0	0	ND	0	0	0	0	0	0	0	0	ND	5269
34	80	M	0	0	ND	0	0	0	0	0	0	0	0	ND	7022
35	81	M	0	0	ND	0	0	0	0	0	0	0	0	ND	3510
36	63	F	0	0	ND	0	0	0	0	0	0	0	0	ND	3205
37	70	M	0	0	ND	0	0	0	0	0	0	0	0	type 16	7315
38	70	M	0	0	ND	0	0	0	0	0	0	0	0	ND	705
39	88	F	0	0	ND	0	0	0	0	0	0	0	0.18	type 18	170
HCMV-P1^a			827.37	2.01											17
HCMV-P2			671.98	270.96											123
HCMV-P3			3955.12	3748.20											10
MCPyV-P1						25879.50									188
MCPyV-P2						28.95									275
HPyV6-P1							107.60								92
HPyV6-P2							2.12								10
HPyV6-P3							0.20								254
HPyV7-P1								0.12							26
HPyV7-P2								0.45							10
HPyV7-P3								0.45							672
EBV-P1										61315.24					2316
EBV-P2										47466.54					2520
HHV8-P1											49621.12				1624
HPV16-P1												3.66			32
HPV16-P2												235.94			228
HPV16-P3												491.46			348
HPV16-P4												46.06			522
HPV18-P1													0.11		496
HPV18-P2													82.98		572
HPV18-P3													4.58		1191
HPV18-P4													0.04		10

*Viral DNA copy number is shown as per reaction.
**Results of nested PCR are also shown.
***Results of nested PCR and the HPV type are shown.
^aPositive controls are as follows: HCMV-P1, HCMV⁺ pancreatitis (FFPE); HCMV-P2, HCMV⁺ enteritis (FFPE); HCMV-P3, HCMV⁺ pneumonia; MCPyV-P1, MCPyV⁺ Merkel cell carcinoma (FFPE); MCPyV-P2, MCPyV⁺ cutaneous squamous cell carcinoma (FFPE); HPyV6-P1, HPyV6⁺ basal cell carcinoma (FFPE); HPyV6-P2, HPyV6⁺ melanoma (FFPE); HPyV6-P3, HPyV6⁺ cutaneous squamous cell carcinoma (FFPE); HPyV7-P1, HPyV7⁺ basal cell carcinoma (FFPE); HPyV7-P2, HPyV7⁺ melanoma (FFPE); HPyV7-P3, HPyV7⁺ cutaneous squamous cell carcinoma (FFPE); EBV-P1 and -P2, EBV⁺ lymphoblastoid cells (cell lines); HHV8-P1, HHV8⁺ KS-1 (cell line); HPV16-P1 and -P2, HPV16⁺ cervical cancer (FFPE); HPV16-P3 and –P4, HPV16⁺ oropharyngeal cancer (FFPE); HPV18-P1 and –P2, HPV18⁺ cervical cancer (FFPE); HPV18-P3 and –P4, HPV18⁺ oropharyngeal cancer (FFPE).
F: female; M: male; ND: not detected.

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