Expression of bcl-2 and p53 in bovine cutaneous fibropapillomas

Table 1 BPV 1/2 DNA presence and bcl-2 and p53 protein expression in normal skin and bovine cutaneous fibropapillomas

Sample	BPV 1/2 DNA	Bcl-2			p53
Sample	BPV 1/2 DNA	Staining	Pattern	Intensity	Staining	Pattern	Intensity
T1	+	Yes	Cytoplasmic, Membranous	+++	Yes	Cytoplasmic Perinuclear	++
T2	+	Yes	Cytoplasmic, Membranous	+++	Yes	Cytoplasmic Perinuclear	+++
T3	+	Yes	Cytoplasmic, Membranous	++	Yes	Cytoplasmic Perinuclear	++
T4	+	Yes	Cytoplasmic, Membranous	++	Yes	Cytoplasmic Perinuclear	+++
T5	+	Yes	Cytoplasmic, Membranous	+++	Yes	Cytoplasmic Perinuclear	+
T6	+	No	No	-	Yes	Cytoplasmic Perinuclear	+
T7	+	Yes	Cytoplasmic	+++	Yes	Cytoplasmic	+
T8	+	Yes	Cytoplasmic, Membranous	++	No	No No	-
T9	+	No	No	-	No	No No	-
T10	+	Yes	Cytoplasmic, Membranous	+	Yes	Cytoplasmic Perinuclear	++
T11	+	No	No	-	No	No	-
T12	+	Yes	Cytoplasmic	++	Yes	Cytoplasmic Perinuclear	+++
N1	+	Yes	Cytoplasmic	+	Yes	Cytoplasmic	+
N2	+	Yes	Cytoplasmic	+	Yes	Cytoplasmic Perinuclear	++

The presence of BPV 1/2 DNA is indicated by “+”. The cellular pattern of the immunoreactivity is either indicated with cytoplasmic and/or membranous and/or perinuclear. The intensity of immunolabelling for each specimen was scored in a “blind study” on a four-tiered scale: −, absent; +, weak signal or very weak signal; ++, moderate signal; +++, strong signal. “T” stands for tumour samples and “N” stands for normal skin samples.

ISSN: 1750-9378