Skip to main content

Table 1 Hazard ratios of incident cervical cancer and cervical intraepithelial neoplasia for the two evaluated genetic risk scores

From: Polygenic risk scores for cervical HPV infection, neoplasia and cancer show potential for personalised screening: comparison of two methods

PRS

Reference group

Cervical cancer (CC)

Cervical intraepithelial neoplasia (CIN)

LDpred HR (95% CI)

BayesRR-RC HR (95% CI)

LDpred HR (95% CI)

BayesRR-RC HR (95% CI)

Top 40%

Remaining 60%

1.59 (1.20–2.11)

1.42 (1.07–1.88)

1.61 (1.43–1.82)

1.72 (1.51–1.95)

Top 20%

Remaining 80%

1.49 (1.08–2.04)

1.60 (1.17–2.19)

1.62 (1.42–1.86)

1.68 (1.46–1.93)

Top 20%

Bottom 20%

2.50 (1.51–4.14)

2.32 (1.43–3.74)

2.38 (1.93–2.95)

2.42 (1.95–3.00)

Top 20%

Below the median

1.66 (1.17–2.35)

1.58 (1.13–2.21)

1.91 (1.64–2.22)

1.98 (1.70–2.32)

Top 10%

Remaining 90%

1.40 (0.93–2.11)

1.62 (1.10–2.39)

1.56 (1.31–1.86)

1.71 (1.44–2.03)

Top 5%

Remaining 95%

1.63 (0.96–2.76)

1.69 (1.01–2.82)

1.68 (1.34–2.11)

2.00 (1.61–2.48)