Table 2 Sensitivity and specificity of cytology, hrHPV, HPV16/18 genotyping and DNA methylation for detecting CIN3+ 

Cytology

71.4% (42.0–90.4%)

78.3% (65.4–87.5%)

0.749 (0.598–0.900)

hrHPV

92.9% (64.2–99.6%)

76.7% (63.7–86.2%)

0.848 (0.744–0.952)

HPV16/18

50.0% (24.0–76.0%)

95.0% (85.2–98.7%)

0.725 (0.55–0.898)

Methylation markers^a

miR124-2^m

JAM3^m

LOC100289333^m

ZIC1^m

SOX1^m

64.3% (35.6–86.0%)

50.0% (24.0–76.0%)

85.7% (56.2–97.5%)

78.6% (48.8–94.3%)

85.7% (56.2–97.5%)

88.3% (76.8–94.8%)

100.0% (92.5–100.0%)

86.7% (74.9–93.7%)

88.3% (76.8–94.8%)

90.0% (78.8–95.9%)

0.763 (0.605–0.922)

0.750 (0.576–0.924)

0.862 (0.744–0.980)

0.835 (0.700–0.969)

0.879 (0.763–0.994)