Table 3 Binary logistic regression analysis of factors influencing the risk of CIN 3 + in HPV 16/18-positive women
Characteristics | CIN 3 + versus ≤ CIN 2 |
|---|---|
OR (95% CI) | |
Age | 1.017 (1.011–1.024) |
Vaginal bleeding | Â |
 No | Reference |
 Yes | 2.674 (2.113–3.384) |
Cytology | Â |
 NILM | Reference |
 ASC-US | 2.339 (1.948–2.808) |
 LSIL | 3.477 (2.836–4.264) |
 ASC-H | 17.339 (13.223–22.736) |
 AGC | 14.963 (9.562–24.413) |
 HSIL +  | 65.466 (50.234–85.316) |
HPV infection patterns | Â |
 Single HPV 16 | Reference |
 HPV 16 + other hrHPVs | 0.621 (0.511–0.755) |
 HPV 16 + lrHPVs | 0.620 (0.436–0.883) |
 HPV 16 + lrHPVs + other hrHPVs | 0.248 (0.157–0.391) |
 Single HPV 18 | 0.327 (0.255–0.420) |
 HPV 18 + other hrHPVs | 0.229 (0.153–0.342) |
 HPV 18 + lrHPVs | 0.315 (0.149–0.665) |
 HPV 18 + lrHPVs + other hrHPVs | 0.210 (0.094–0.467) |
 HPV 18 + HPV 16 | 0.747 (0.364–1.534) |
 HPV 18 + HPV 16 + other hrHPVs | 0.710 (0.322–1.562) |
 HPV 18 + HPV 16 + lrHPVs | NA |
 HPV 18 + HPV 16 + lrHPVs + other hrHPVs | 0.370 (0.076–1.801) |