Table 1 Clinical and demographic information of the general cohort

Gender

 Female

87 (64%)

 Male

49 (36%)

Age

64 (11)

Weight (kg)

69 (12)

Height (m)

11 (39)

BMI

25.9 (4.1)

Nutritional status

 normal weight

55 (40%)

 obese

21 (15%)

 overweight

58 (43%)

 underweight

2 (1.5%)

Oncological treatment

 CT

64 (47%)

 CT + IO

37 (27%)

 IO

35 (26%)

Concomitant disease

97 (71%)

 Cardiovascular disease

57 (42%)

 Metabolic disease

31 (23%)

 Hematologic disease

3 (2.2%)

 Immune-mediated

5 (3.7%)

 Lung disease

7 (5.1%)

 Liver disease

5 (3.7%)

 Psychiatric disorders

2 (1.5%)

 Allergy to drugs

20 (15%)

 Endocrine disease

11 (8.1%)

 Early disease

19 (14%)

 Advanced disease

117 (86%)

Antibody before vaccine

 Negative

94 (85%)

 Positive

17 (15%)

Antibody Titer one-month

 Negative

81 (81%)

 Positive

19 (19%)

Antibody Titer at 3-months

 Negative

70 (84%)

 Positive

13 (16%)

Antibody Titer at 6-months

 Negative

45 (82%)

 Positive

10 (18%)

Growth factors use

 No

114 (84%)

 Yes

22 (16%)